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Biological Activity for RHC 80267
RHC 80267 is an inhibitor of diacylglycerol lipase (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM).
Technical Data for RHC 80267
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RHC 80267
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for RHC 80267
The following data is based on the product molecular weight 394.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.53 mL||12.67 mL||25.35 mL|
|5 mM||0.51 mL||2.53 mL||5.07 mL|
|10 mM||0.25 mL||1.27 mL||2.53 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References for RHC 80267
References are publications that support the biological activity of the product.
Ghisdal et al (2005) The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol. 517 97 PMID: 15958263
Sutherland and Amin (1982) Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. J.Biol.Chem. 257 14006 PMID: 7142192
Suzuki et al (2002) Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res. 38 153 PMID: 12713022
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Keywords: RHC 80267, RHC 80267 supplier, Diacylglycerol, lipases, inhibitors, inhibits, PLC, PLA2, Phospholipases, C, A, Esterases, Lipid, Metabolism, DAGL, RHC80267, U57908, U, 57908, Lipases, Phospholipase, Other, 1842, Tocris Bioscience
4 Citations for RHC 80267
Citations are publications that use Tocris products. Selected citations for RHC 80267 include:
Breunig et al (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. Am J Physiol Gastrointest Liver Physiol 30 8965 PMID: 20592217
Skinner et al (2009) Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem 284 30941 PMID: 19748893
Skinner et al (2013) Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2 80 PMID: 23805403
Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545 PMID: 21844187
Do you know of a great paper that uses RHC 80267 from Tocris? Please let us know.
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