RHC 80267

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Cat.No. 1842 - RHC 80267 | C20H34N4O4 | CAS No. 83654-05-1
Description: Diacylglycerol lipase inhibitor
Alternative Names: U 57908
Chemical Name: O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Literature

Biological Activity

Inhibitor of diacylglycerol lipase (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM).

Compound Libraries

RHC 80267 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 394.51
Formula C20H34N4O4
Storage Store at +4°C
Purity ≥95% (HPLC)
CAS Number 83654-05-1
PubChem ID 5063
InChI Key RXSVYGIGWRDVQC-UHFFFAOYSA-N
Smiles O=C(NCCCCCCNC(O/N=C2\CCCCC2)=O)O/N=C1CCCCC/1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100
ethanol 39.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 394.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ghisdal et al (2005) The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol. 517 97 PMID: 15958263

Sutherland and Amin (1982) Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. J.Biol.Chem. 257 14006 PMID: 7142192

Suzuki et al (2002) Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res. 38 153 PMID: 12713022


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View Related Products by Product Action

View all Other Lipid Metabolism Inhibitors

Keywords: RHC 80267, supplier, Diacylglycerol, lipases, inhibitors, inhibits, PLC, PLA2, Phospholipases, C, A, Esterases, Lipid, Metabolism, DAGL, RHC80267, U57908, U, 57908, Other, Lipid, Metabolism, Tocris Bioscience

4 Citations for RHC 80267

Citations are publications that use Tocris products. Selected citations for RHC 80267 include:

Skinner et al (2013) Perilipin 1 moves between the fat droplet and the endoplasmic reticulum. Adipocyte 2 80 PMID: 23805403

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545 PMID: 21844187

Breunig et al (2010) The endocannabinoid 2-arachidonoyl-glycerol controls odor sensitivity in larvae of Xenopus laevis. Am J Physiol Gastrointest Liver Physiol 30 8965 PMID: 20592217

Skinner et al (2009) Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem 284 30941 PMID: 19748893


Do you know of a great paper that uses RHC 80267 from Tocris? If so please let us know.

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