U 73343

Pricing Availability Delivery Time Qty
Cat.No. 4133 - U 73343 | C29H42N2O3 | CAS No. 142878-12-4
Description: Analog of U 73122 (Cat. No. 1268)
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Literature

Biological Activity

Analog of U 73122 (Cat. No. 1268); can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Technical Data

M. Wt 466.66
Formula C29H42N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 142878-12-4
PubChem ID 114825
InChI Key CJHWFIUASFBCKN-ZRJUGLEFSA-N
Smiles [H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.67 10mM with gentle warming
ethanol 2.33 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 466.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.14 mL 10.71 mL 21.43 mL
5 mM 0.43 mL 2.14 mL 4.29 mL
10 mM 0.21 mL 1.07 mL 2.14 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 282 1379 PMID: 9316850

Kataoka et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 108 115 PMID: 19014371

Ma et al (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 328 409 PMID: 19023039

Berven and Barritt (1995) Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 49 1373 PMID: 7763279


If you know of a relevant reference for U 73343, please let us know.

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Keywords: U 73343, supplier, U73343, negative, control, analog, U73122, plc, phospholipases, c, Phospholipases, Tocris Bioscience

7 Citations for U 73343

Citations are publications that use Tocris products. Selected citations for U 73343 include:

Osman et al (2016) Detachment of surface membrane invagination systems by cationic amphiphilic drugs. PLoS One 6 18536 PMID: 26725955

Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634

Yoon et al (2015) The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Sci Rep 2015 843024 PMID: 26640326

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS One 10 e0140369 PMID: 26460748

Rioult-Pedotti et al (2015) Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Cereb Blood Flow Metab 10 e0124986 PMID: 25938462

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333


Do you know of a great paper that uses U 73343 from Tocris? If so please let us know.

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