U 73343

Pricing Availability   Qty
Cat.No. 4133 - U 73343 | C29H42N2O3 | CAS No. 142878-12-4
Description: Analog of U 73122 (Cat. No. 1268)
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)
Datasheet
Citations (13)
Reviews
Literature (3)

Biological Activity

Analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data

M. Wt 466.66
Formula C29H42N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 142878-12-4
PubChem ID 114825
InChI Key CJHWFIUASFBCKN-ZRJUGLEFSA-N
Smiles [H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.67 10 with gentle warming
ethanol 2.33 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 466.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.43 mL 107.14 mL 214.29 mL
0.5 mM 4.29 mL 21.43 mL 42.86 mL
1 mM 2.14 mL 10.71 mL 21.43 mL
5 mM 0.43 mL 2.14 mL 4.29 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 282 1379 PMID: 9316850

Kataoka et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 108 115 PMID: 19014371

Ma et al (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 328 409 PMID: 19023039

Berven and Barritt (1995) Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 49 1373 PMID: 7763279


If you know of a relevant reference for U 73343, please let us know.

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View all Phospholipase Inhibitors

Keywords: U 73343, U 73343 supplier, U73343, negative, control, analog, U73122, plc, phospholipases, c, Phospholipases, Phospholipase, C, 4133, Tocris Bioscience

13 Citations for U 73343

Citations are publications that use Tocris products. Selected citations for U 73343 include:

Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. ELife 9 e52160 PMID: 31913121

Brenner et al (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 155 2124 PMID: 25109670

Yoon et al (2015) The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Sci Rep 2015 843024 PMID: 26640326

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS One 10 e0140369 PMID: 26460748


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Literature in this Area

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