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U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.
Active Analog also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||4.67||10 with gentle warming|
|ethanol||2.33||5 with gentle warming|
The following data is based on the product molecular weight 466.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.43 mL||107.14 mL||214.29 mL|
|0.5 mM||4.29 mL||21.43 mL||42.86 mL|
|1 mM||2.14 mL||10.71 mL||21.43 mL|
|5 mM||0.43 mL||2.14 mL||4.29 mL|
References are publications that support the biological activity of the product.
Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 282 1379 PMID: 9316850
Kataoka et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 108 115 PMID: 19014371
Ma et al (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 328 409 PMID: 19023039
Berven and Barritt (1995) Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 49 1373 PMID: 7763279
If you know of a relevant reference for U 73343, please let us know.
Keywords: U 73343, U 73343 supplier, U73343, negative, control, analog, U73122, plc, phospholipases, c, Phospholipases, Phospholipase, C, 4133, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for U 73343 include:
Osman et al (2016) Detachment of surface membrane invagination systems by cationic amphiphilic drugs. PLoS One 6 18536 PMID: 26725955
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. ELife 9 e52160 PMID: 31913121
Brenner et al (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 155 2124 PMID: 25109670
Yoon et al (2015) The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Sci Rep 2015 843024 PMID: 26640326
Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS One 10 e0140369 PMID: 26460748
Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Cereb Blood Flow Metab 10 e0124986 PMID: 25938462
Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634
Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481
Atakpa et al (2018) IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep 25 3180 PMID: 30540949
Rajan et al (2017) A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell 43 83 PMID: 29017032
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212
Ruisanchez et al (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J 28 880 PMID: 24249637
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