U 73343

Pricing Availability   Qty
Description: Analog of U 73122 (Cat. No. 1268)
Chemical Name: 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
Purity: ≥98% (HPLC)
Citations (20)

Biological Activity for U 73343

U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.

Active Analog also available.

Technical Data for U 73343

M. Wt 466.66
Formula C29H42N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 142878-12-4
PubChem ID 114825
Smiles [H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for U 73343

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.67 10 with gentle warming
ethanol 2.33 5 with gentle warming

Preparing Stock Solutions for U 73343

The following data is based on the product molecular weight 466.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.43 mL 107.14 mL 214.29 mL
0.5 mM 4.29 mL 21.43 mL 42.86 mL
1 mM 2.14 mL 10.71 mL 21.43 mL
5 mM 0.43 mL 2.14 mL 4.29 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for U 73343

Certificate of Analysis / Product Datasheet
Select another batch:

References for U 73343

References are publications that support the biological activity of the product.

Muto et al (1997) The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 282 1379 PMID: 9316850

Kataoka et al (2009) Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 108 115 PMID: 19014371

Ma et al (2009) Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 328 409 PMID: 19023039

Berven and Barritt (1995) Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 49 1373 PMID: 7763279

If you know of a relevant reference for U 73343, please let us know.

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: U 73343, U 73343 supplier, U73343, negative, control, analog, U73122, plc, phospholipases, c, Phospholipases, Phospholipase, C, 4133, Tocris Bioscience

20 Citations for U 73343

Citations are publications that use Tocris products. Selected citations for U 73343 include:

Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212

Ruisanchez et al (2014) Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. FASEB J 28 880 PMID: 24249637

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333

Samir et al (2023) Oxytocin excites dorsal raphe serotonin neurons and bidirectionally gates their glutamate synapses. iScience 26 106707 PMID: 37250336

Lino et al (2020) Novel metabolic role for BDNF in pancreatic β-cell insulin secretion. Nat Commun 11 1950 PMID: 32327658

Rajan et al (2017) A Mechanism Coupling Systemic Energy Sensing to Adipokine Secretion. Dev Cell 43 83 PMID: 29017032

Babola et al (2020) Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. ELife 9 e52160 PMID: 31913121

Atakpa et al (2018) IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes. Cell Rep 25 3180 PMID: 30540949

Yoon et al (2015) The Effect of Therapeutic Blockades of Dust Particles-Induced Ca2+ Signaling and Proinflammatory Cytokine IL-8 in Human Bronchial Epithelial Cells. Sci Rep 2015 843024 PMID: 26640326

Montalbano et al (2015) Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PLoS One 10 e0140369 PMID: 26460748

Rioult-Pedotti et al (2015) DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation. J Cereb Blood Flow Metab 10 e0124986 PMID: 25938462

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252 PMID: 26269634

Jeong Hee et al (2017) Dust particles-induced intracellular Ca2+ signaling and reactive oxygen species in lung fibroblast cell line MRC5. Korean J Physiol Pharmacol 21 327-334 PMID: 28461775

Zhen et al (2009) Phosphatidylinositol (4,5)-bisphosphate regulation of N-methyl-D-aspartate receptor channels in cortical neurons. Mol Pharmacol 76 1349-59 PMID: 19770351

Giovanni et al (2019) Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. Cell 177 1280-1292.e20 PMID: 31031006

Thomas A et al (2019) A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila. Nature 574 559-564 PMID: 31645735

Osman et al (2016) Detachment of surface membrane invagination systems by cationic amphiphilic drugs. PLoS One 6 18536 PMID: 26725955

Brenner et al (2014) A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo. Pain 155 2124 PMID: 25109670

Dhurgham et al (2022) Regulation of Focal Adhesion Dynamics and Cell Migration by PLC/PI3K-Mediated Metabolism of PtdIns (4,5) P2 in a Breast Cancer Cell Line. Rep Biochem Mol Biol 11 270-281 PMID: 36164622

Do you know of a great paper that uses U 73343 from Tocris? Please let us know.

Reviews for U 73343

There are currently no reviews for this product. Be the first to review U 73343 and earn rewards!

Have you used U 73343?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review