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Tocrisolve™ 100 is a formulation composed of a 1:4 ratio of soya oil/water which is emulsified with the block co-polymer, Pluronic F68. Lipids in Tocrisolve™ can be conveniently diluted with any aqueous medium for further use.
The cannabinoid or vanilloid is incorporated with the emulsion as part of a specialized innovative production process. The soya oil forms a coating around the cannabinoid molecule, and the block co-polymer is added to stabilize the emulsion, preventing the lipid droplets from coalescing (merging) in the surrounding water.
Tocrisolve products must not be stored at -20°C as freezing has an adverse effect on the stability of the formulation. Provided that the vial is kept tightly sealed, protected from exposure to light and stored at +4°C, the product should be stable for 1 month from the date of despatch.
The emulsion can be diluted to any extent with aqueous medium, including water, saline and HEPES buffer. The solution can be used for in vitro or in vivo experiments, as has been reported for anandamide in Tocrisolve™ 100 (Cat. No. 1017) in the following papers:
Tocris is a Bio-Techne brand. To find out more please visit our news page.