AM 404 (in Tocrisolve™ 100)

Discontinued Product

AM 404 (in Tocrisolve™ 100) (Cat. No. 1685) has been withdrawn from sale for commercial reasons.
Cat.No. 1685 - AM 404 (in Tocrisolve 100) | C26H37NO2 | CAS No. 198022-70-7
Description: Anandamide transport inhibitor (in water-soluble emulsion)
Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available as solid AM 404 (Cat. No. 1116).

Technical Data

M. Wt 395.58
Formula C26H37NO2
Storage Store at +4°C
CAS Number 198022-70-7
PubChem ID 6604822
Smiles O=C(NC1=CC=C(O)C=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094 PMID: 9262477

Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1 PMID: 9389389

Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802 PMID: 10318965

Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39 PMID: 10822052

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2 Citations for AM 404 (in Tocrisolve™ 100)

Citations are publications that use Tocris products. Selected citations for AM 404 (in Tocrisolve™ 100) include:

Costa et al (2014) 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction 147 301 PMID: 24324206

Tan et al (2011) Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex. J Neurosci 31 5300 PMID: 21471365


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