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Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available as solid AM 404 (Cat. No. 1116).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094 PMID: 9262477
Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1 PMID: 9389389
Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802 PMID: 10318965
Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39 PMID: 10822052
Keywords: AM 404 (in Tocrisolve 100), AM 404 (in Tocrisolve 100) supplier, Vanilloid, receptor, agonists, anandamide, transporters, inhibitors, inhibits, water-soluble, emulsion, Anandamide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, AMT, cannabinoids, Monoamine, Neurotransmitter, AM404, Cannabinoid, Transporters, 1685, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for AM 404 (in Tocrisolve™ 100) include:
Costa et al (2014) 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction 147 301 PMID: 24324206
Tan et al (2011) Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex. J Neurosci 31 5300 PMID: 21471365
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.