AM 404 (in Tocrisolve™ 100)

Discontinued Product

AM 404 (in Tocrisolve™ 100) (Cat. No. 1685) has been withdrawn from sale for commercial reasons.
Description: Anandamide transport inhibitor (in water-soluble emulsion)
Chemical Name: N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Citations (2)
Literature (2)

Biological Activity for AM 404 (in Tocrisolve™ 100)

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC50 = 1 μM), in water-soluble emulsion (for details see TocrisolveTM 100 Cat. No. 1684). Does not activate CB1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC50 = 7.4). Active in vivo. Also available as solid AM 404 (Cat. No. 1116).

Technical Data for AM 404 (in Tocrisolve™ 100)

M. Wt 395.58
Formula C26H37NO2
Storage Store at +4°C
CAS Number 198022-70-7
PubChem ID 6604822

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AM 404 (in Tocrisolve™ 100)

Certificate of Analysis / Product Datasheet
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References for AM 404 (in Tocrisolve™ 100)

References are publications that support the biological activity of the product.

Beltramo et al (1997) Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science 277 1094 PMID: 9262477

Calignano et al (1997) Potentiation of anandamide hypotension by the transport inhibitor, AM 404. Eur.J.Pharmacol. 337 R1 PMID: 9389389

Piomelli et al (1999) Structural determinants for recognition and translocation by the anandamide transporter. Proc.Natl.Acad.Sci.U.S.A. 96 5802 PMID: 10318965

Zygmunt et al (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur.J.Pharmacol. 396 39 PMID: 10822052

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2 Citations for AM 404 (in Tocrisolve™ 100)

Citations are publications that use Tocris products. Selected citations for AM 404 (in Tocrisolve™ 100) include:

Tan et al (2011) Cannabinoid transmission in the basolateral amygdala modulates fear memory formation via functional inputs to the prelimbic cortex. J Neurosci 31 5300 PMID: 21471365

Costa et al (2014) 2-arachidonoylglycerol effects in cytotrophoblasts: metabolic enzymes expression and apoptosis in BeWo cells. Reproduction 147 301 PMID: 24324206

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

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Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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