JWH 133 (in Tocrisolve™ 100)

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Cat.No. 1783 - JWH 133 (in Tocrisolve 100) | C22H32O | CAS No. 259869-55-1
Description: Potent, selective CB2 agonist (in water-soluble emulsion)
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Citations (1)

Biological Activity

Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.

JWH 133 available as a solid.Tocrisolve Control also available.

Technical Data

M. Wt 312.49
Formula C22H32O
Storage Store at +4°C
CAS Number 259869-55-1
PubChem ID 6918505
Smiles [H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 312.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16 mL 32 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Baker et al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84 PMID: 10716447

Huffman et al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884

If you know of a relevant reference for JWH 133 (in Tocrisolve™ 100), please let us know.

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1 Citation for JWH 133 (in Tocrisolve™ 100)

Citations are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:

Williams et al (2014) △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. Autophagy 9 369 PMID: 24562630

Do you know of a great paper that uses JWH 133 (in Tocrisolve™ 100) from Tocris? If so please let us know.

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