JWH 133 (in Tocrisolve™ 100)

Discontinued Product

Unfortunately JWH 133 (in Tocrisolve™ 100) (Cat. No. 1783) has been withdrawn from sale for commercial reasons.
Cat.No. 1783 - JWH 133 (in Tocrisolve 100) | C22H32O | CAS No. 259869-55-1
Description: Potent, selective CB2 agonist (in water-soluble emulsion)
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.

JWH 133 available as a solid.Tocrisolve Control also available.

Technical Data

M. Wt 312.49
Formula C22H32O
Storage Store at +4°C
CAS Number 259869-55-1
PubChem ID 6918505
InChI Key YSBFLLZNALVODA-RBUKOAKNSA-N
Smiles [H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Baker et al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84 PMID: 10716447

Huffman et al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884

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Keywords: JWH 133 (in Tocrisolve 100), supplier, Potent, selective, CB2, agonists, water-soluble, emulsion, cannabinoids, Receptors, JWH133, cb2r, CB2, Receptors, CB2, Receptors, Tocris Bioscience

1 Citation for JWH 133 (in Tocrisolve™ 100)

Citations are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:

Williams et al (2014) △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. Autophagy 9 369 PMID: 24562630


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Literature in this Area

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