JWH 133 (in Tocrisolve™ 100)

Discontinued Product

JWH 133 (in Tocrisolve™ 100) (Cat. No. 1783) has been withdrawn from sale for commercial reasons.
Description: Potent, selective CB2 agonist (in water-soluble emulsion)
Chemical Name: (6aR,10aR)-3-(1,1-dimethylbutyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Citations (1)
Literature (1)

Biological Activity for JWH 133 (in Tocrisolve™ 100)

Potent CB2 selective agonist (Ki = 3.4 nM), in water-soluble emulsion (for details see TocrisolveTM 100). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.

JWH 133 available as a solid.

Technical Data for JWH 133 (in Tocrisolve™ 100)

M. Wt 312.49
Formula C22H32O
Storage Store at +4°C
CAS Number 259869-55-1
PubChem ID 6918505
Smiles [H][C@]([C@]3([H])C(C)(C)O2)(CC(C)=CC3)C1=C2C=C(C(C)(C)CCC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for JWH 133 (in Tocrisolve™ 100)

Certificate of Analysis / Product Datasheet
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References for JWH 133 (in Tocrisolve™ 100)

References are publications that support the biological activity of the product.

Baker et al (2000) Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature 404 84 PMID: 10716447

Huffman et al (1999) 3-(1'-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905 PMID: 10658595

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884

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Keywords: JWH 133 (in Tocrisolve 100), JWH 133 (in Tocrisolve 100) supplier, Potent, selective, CB2, agonists, water-soluble, emulsion, cannabinoids, Receptors, JWH133, cb2r, 1783, Tocris Bioscience

1 Citation for JWH 133 (in Tocrisolve™ 100)

Citations are publications that use Tocris products. Selected citations for JWH 133 (in Tocrisolve™ 100) include:

Williams et al (2014) △(9)-Tetrahydrocannabinol treatment during human monocyte differentiation reduces macrophage susceptibility to HIV-1 infection. Autophagy 9 369 PMID: 24562630

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.