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Description: Selective non-ATP competitive inhibitor of GSK 3β
Alternative Names: NP 01139
Chemical Name: 2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)
Literature (4)
Pathways (1)

Biological Activity for TDZD 8

TDZD 8 is a selective non-ATP competitive inhibitor of GSK 3β (IC50 = 2 μM); thiadiazolidinone deriviative. Does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. Reduces severity of L-dopa-induced dyskinesia in a Parkinson's disease in vivo model.

Technical Data for TDZD 8

M. Wt 222.26
Formula C10H10N2O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 327036-89-5
PubChem ID 4124851
Smiles CN1SC(N(C1=O)CC2=CC=CC=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TDZD 8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.23 100
ethanol 22.23 100

Preparing Stock Solutions for TDZD 8

The following data is based on the product molecular weight 222.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.5 mL 44.99 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

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References for TDZD 8

References are publications that support the biological activity of the product.

Xie et al (2016) Inhibition of Glycogen Synthase Kinase-3β (GSK-3 beta ) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats. Sci.Rep. 6 23527 PMID: 26997328

Martinez et al (2002) First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J.Med.Chem. 45 1292 PMID: 11881998

If you know of a relevant reference for TDZD 8, please let us know.

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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: TDZD 8, TDZD 8 supplier, TDZD8, NP01139, NP_01139, Selective, non-ATP, competitive, inhibitor, GSK, 3, β, L-dopa-induced, dyskinesia, NP, 01139, Glycogen, Synthase, Kinase, 6092, Tocris Bioscience

1 Citation for TDZD 8

Citations are publications that use Tocris products. Selected citations for TDZD 8 include:

Coleen M et al (2020) Glycogen synthase kinase-3 inhibition rescues sex-dependent contextual fear memory deficit in human immunodeficiency virus-1 transgenic mice. Br J Pharmacol 177 5658-5676 PMID: 33080056

Do you know of a great paper that uses TDZD 8 from Tocris? Please let us know.

Reviews for TDZD 8

Average Rating: 5 (Based on 1 Review.)

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Great GSK3 inhibitor.
By Anonymous on 11/25/2021
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: Brain

I have used TDZD to inhibit GSK3 in the brain of mice. After the treatment, we investigated if the NCS-1 gene would increase its expression as we have hypothesised the GSK3 protein impairs NCS-1 gene expression. We found that this happened, but only in the pre frontal cortex (PFC) as showed by the figure.

We treated mice with TDZD-8 at 30 mg/kg, i.p. for 1 h

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Stem Cells Poster

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Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for TDZD 8

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.