TCS 21311

Pricing Availability   Qty
Description: Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
Alternative Names: NIBR3049
Chemical Name: 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for TCS 21311

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Compound Libraries for TCS 21311

TCS 21311 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TCS 21311

M. Wt 526.51
Formula C27H25F3N4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1260181-14-3
PubChem ID 50925411
Smiles O=C(N1)C(C3=CNC4=C3C=CC=C4)=C(C2=C(C(F)(F)F)C=CC(N5CCN(C(C(O)(C)C)=O)CC5)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TCS 21311

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.65 100

Preparing Stock Solutions for TCS 21311

The following data is based on the product molecular weight 526.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.5 mL 18.99 mL
5 mM 0.38 mL 1.9 mL 3.8 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References for TCS 21311

References are publications that support the biological activity of the product.

Thoma et al (2010) Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 54 284 PMID: 21155605

If you know of a relevant reference for TCS 21311, please let us know.

View Related Products by Product Action

View all JAK Inhibitors

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Citations for TCS 21311

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Pathways for TCS 21311

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.