SB 772077B dihydrochloride

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Cat.No. 4118 - SB 772077B dihydrochloride | C15H18N8O2.2HCl | CAS No. 607373-46-6
Description: Potent Rho-kinase inhibitor; vasodilator
Chemical Name: (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent Rho-kinase (ROCK) inhibitor (IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat.No 1254) or Fasudil (Cat.No. 0541).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Compound Libraries

SB 772077B dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 415.28
Formula C15H18N8O2.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 607373-46-6
PubChem ID 69157798
InChI Key HSROPTGRSYJPJY-JZGIKJSDSA-N
Smiles NC1=NON=C1C3=NC2=CN=CC(C(N4CC[C@H](N)C4)=O)=C2N3CC.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 41.53 100
DMSO 41.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 415.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.08 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Doe et al (2007) Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J.Pharm.Exp.Ther. 320 89

Dhaliwal et al (2009) Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J.Pharm.Exp.Ther. 330 334


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View all Rho-Kinases Inhibitors

Keywords: SB 772077B dihydrochloride, SB 772077B dihydrochloride supplier, SB772077B, 2HCl, Rho, Kinase, inhibitors, inhibits, ROCK, anti-inflammatory, vasodilators, antihypertensive, Rho-kinases, 4118, Tocris Bioscience

1 Citation for SB 772077B dihydrochloride

Citations are publications that use Tocris products. Selected citations for SB 772077B dihydrochloride include:

Lotz-Jenne et al (2016) A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget 7 25983 PMID: 27036020


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