Discontinued Product

S3QEL 2 (Cat. No. 5735) has been withdrawn from sale for commercial reasons.
Description: Suppressor of complex III superoxide production
Chemical Name: 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)

Biological Activity for S3QEL 2

Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.

Technical Data for S3QEL 2

M. Wt 323.44
Formula C19H25N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 890888-12-7
PubChem ID 17017624
Smiles CC(C(C)=C1)=CC=C1N2C3=NC=NC(N(CCC)CCC)=C3C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for S3QEL 2

References are publications that support the biological activity of the product.

Orr et al (2015) Suppressors of superoxide production from mitochondrial complex III. Nat.Chem.Biol. 11 834 PMID: 26368590

Keywords: S3QEL 2, S3QEL 2 supplier, S3QEL2, Suppresses, superoxide, production, complex, III, mitochondria, oxidative, phosphorylation, ROS, reactive, oxygen, species, inhibitors, inhibits, Donors, Oxidative, Phosphorylation, 5735, Tocris Bioscience

Citations for S3QEL 2

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Currently there are no citations for S3QEL 2.

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