Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||6.47||20 with gentle warming|
|ethanol||6.47||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 323.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.09 mL||15.46 mL||30.92 mL|
|5 mM||0.62 mL||3.09 mL||6.18 mL|
|10 mM||0.31 mL||1.55 mL||3.09 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the biological activity of the product.
Orr et al (2015) Suppressors of superoxide production from mitochondrial complex III. Nat.Chem.Biol. 11 834 PMID: 26368590
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Keywords: S3QEL 2, S3QEL 2 supplier, S3QEL2, Suppresses, superoxide, production, complex, III, mitochondria, oxidative, phosphorylation, ROS, reactive, oxygen, species, inhibitors, inhibits, Donors, Oxidative, Phosphorylation, 5735, Tocris Bioscience
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