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Cat.No. 5735 - S3QEL 2 | C19H25N5 | CAS No. 890888-12-7
Description: Suppressor of complex III superoxide production
Chemical Name: 1-(3,4-Dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Suppresses superoxide production by complex III in the mitochondria without affecting normal electron flux or cellular oxidative phosphorylation (IC50 = 1.7 μM). Suppresses HIF-1α accumulation and enhances survival and function of primary pancreatic islets in vitro. Cell permeable.

Technical Data

M. Wt 323.44
Formula C19H25N5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 890888-12-7
PubChem ID 17017624
Smiles CC(C(C)=C1)=CC=C1N2C3=NC=NC(N(CCC)CCC)=C3C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.47 20 with gentle warming
ethanol 6.47 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 323.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.46 mL 77.29 mL 154.59 mL
1 mM 3.09 mL 15.46 mL 30.92 mL
2 mM 1.55 mL 7.73 mL 15.46 mL
10 mM 0.31 mL 1.55 mL 3.09 mL

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References are publications that support the biological activity of the product.

Orr et al (2015) Suppressors of superoxide production from mitochondrial complex III. Nat.Chem.Biol. 11 834 PMID: 26368590

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