Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Review(S)-3-Carboxy-4-hydroxyphenylglycine
Discontinued Product
0329 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Group I mGlu antagonist; also group II mGlu agonist
Alternative Names: (S)-3C4HPG
Purity: ≥98% (HPLC)
Biological Activity for (S)-3-Carboxy-4-hydroxyphenylglycine
(S)-3-Carboxy-4-hydroxyphenylglycine is a mixed group I metabotropic glutamate receptor antagonist and group II mGlu agonist.
R-enantiomer also available.
Technical Data for (S)-3-Carboxy-4-hydroxyphenylglycine
| M. Wt | 211.17 |
| Formula | C9H9NO5 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 55136-48-6 |
| PubChem ID | 5311460 |
| InChI Key | CHZBCZTXSTWCIG-ZETCQYMHSA-N |
| Smiles | OC1=C(C(O)=O)C=C([C@]([H])(N)C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (S)-3-Carboxy-4-hydroxyphenylglycine
References for (S)-3-Carboxy-4-hydroxyphenylglycine
References are publications that support the biological activity of the product.
Hayashi et al (1994) Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor sub-types. J.Neurosci. 14 3370 PMID: 8182479
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
Watkins and Collingridge (1994) Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. TiPS 15 333 PMID: 7992387
Watkins et al (1987) Recent advances in the pharmacology of excitatory amino acids. Excitatory Amino Acid Transmission. Eds. Hicks, Lo 19-26
View Related Products by Target
View Related Products by Product Action
View all Glutamate (Metabotropic) Group I Receptor Antagonists
Keywords: (S)-3-Carboxy-4-hydroxyphenylglycine, (S)-3-Carboxy-4-hydroxyphenylglycine supplier, Group, I, antagonists, group, II, agonists, Selective, mGlur, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, mGlu2, mGlu3, mGluR2, mGluR3, (S)-3C4HPG, (Metabotropic), 0329, Tocris Bioscience
Citations for (S)-3-Carboxy-4-hydroxyphenylglycine
Citations are publications that use Tocris products.
Currently there are no citations for (S)-3-Carboxy-4-hydroxyphenylglycine.
Reviews for (S)-3-Carboxy-4-hydroxyphenylglycine
There are currently no reviews for this product. Be the first to review (S)-3-Carboxy-4-hydroxyphenylglycine and earn rewards!
Have you used (S)-3-Carboxy-4-hydroxyphenylglycine?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.