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Biological Activity for (R)-3-Carboxy-4-hydroxyphenylglycine
(R)-3-Carboxy-4-hydroxyphenylglycine is a moderately potent NMDA and AMPA/kainate receptor antagonist.
S-enantiomer also available.
Technical Data for (R)-3-Carboxy-4-hydroxyphenylglycine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (R)-3-Carboxy-4-hydroxyphenylglycine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (R)-3-Carboxy-4-hydroxyphenylglycine
The following data is based on the product molecular weight 211.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.74 mL||23.68 mL||47.36 mL|
|5 mM||0.95 mL||4.74 mL||9.47 mL|
|10 mM||0.47 mL||2.37 mL||4.74 mL|
|50 mM||0.09 mL||0.47 mL||0.95 mL|
Product Datasheets for (R)-3-Carboxy-4-hydroxyphenylglycine
References for (R)-3-Carboxy-4-hydroxyphenylglycine
References are publications that support the biological activity of the product.
Watkins et al (1987) Recent advances in the pharmacology of excitatory amino acids. Excitatory Amino Acid Transmission. Eds. Hicks, Lo 19-26
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Citations for (R)-3-Carboxy-4-hydroxyphenylglycine
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.