GABA Receptors Scientific Review

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GABA Receptors Scientific Review

Ian Martin, Norman Bowery & Susan Dunn

Review excerpt: "Despite the overwhelming representation of GPCRs in the human genome, it is the ionotropic receptor for the major inhibitory neurotransmitter GABA that has achieved the most visibility to date. Its serendipitous exploitation within the clinical arena has stimulated a plethora of intriguing insights into the mechanisms by which communication within the nervous system is achieved and the nuances of modulation which provide opportunities for further refinement of pharmacological intervention."