RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 424.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.78 mL||23.56 mL|
|5 mM||0.47 mL||2.36 mL||4.71 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the products' biological activity.
Yan et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 443 PMID: 25219851
If you know of a relevant reference for RBC8, please let us know.
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Keywords: RBC8, supplier, RalA, RalB, ras, like, GTPase, inhibitors, inhibits, antitumour, antitumor, GTPase, G, Proteins, (Small), GTPase, Tocris Bioscience
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