RBC8

Pricing Availability Delivery Time Qty
Cat.No. 5411 - RBC8 | C25H20N4O3 | CAS No. 361185-42-4
Description: RalA and RalB GTPase inhibitor
Chemical Name: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.

Compound Libraries

RBC8 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 424.45
Formula C25H20N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 361185-42-4
PubChem ID 6626226
InChI Key CLMQBVUFKIKYLU-UHFFFAOYSA-N
Smiles NC1=C(C#N)C(C5=C(OC)C=CC(OC)=C5)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN2)=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 424.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yan et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 443 PMID: 25219851


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View all GTPase Inhibitors

Keywords: RalA RalB ras like GTPase inhibitors inhibits antitumour antitumor GTPase

Citations for RBC8

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for RBC8

Protocols

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