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Cat.No. 5411 - RBC8 | C25H20N4O3 | CAS No. 361185-42-4
Description: RalA and RalB GTPase inhibitor
Chemical Name: 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)pyrano[2,3-c]pyrazole-5-carbonitrile
Purity: ≥98% (HPLC)

Biological Activity

RalA and RalB GTPase inhibitor (EC50 ~3.5 μM). Inhibits the binding of Ral to RaLBP1. Exhibits no detectable inhibition of Ras or RhoA activity. Suppresses growth of xenograft tumors in mice. Cell permeable.

Compound Libraries

RBC8 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 424.45
Formula C25H20N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 361185-42-4
PubChem ID 6626226
Smiles NC1=C(C#N)C(C5=C(OC)C=CC(OC)=C5)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN2)=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 424.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References are publications that support the biological activity of the product.

Yan et al (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515 443 PMID: 25219851

If you know of a relevant reference for RBC8, please let us know.

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Keywords: RBC8, RBC8 supplier, RalA, RalB, ras, like, GTPase, inhibitors, inhibits, antitumour, antitumor, G, Proteins, (Small), 5411, Tocris Bioscience

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