(+)-U-50488 hydrochloride

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Cat.No. 0471 - (+)-U-50488 hydrochloride | C19H26Cl2N2O.HCl | CAS No. 114528-81-3
Description: Standard selective κ agonist. Less active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name: trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Less active enantiomer of (±)-U-50488 (Cat. No. 0495). (-)-U-50488 hydrochloride (Cat. No. 0496) also available.

Technical Data

M. Wt 405.79
Formula C19H26Cl2N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 114528-81-3
PubChem ID 6918162
InChI Key KGMMGVIYOHGOKQ-JAXOOIEVSA-N
Smiles O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.58 100
water 40.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490


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View all κ Opioid Receptor Agonists

Keywords: selective agonists enantiomer κ-opioid kappa-opioid KOP Receptors OP2 Kappa Opioid Receptors

Citations for (+)-U-50488 hydrochloride

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Pathways for (+)-U-50488 hydrochloride

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