(±)-U-50488 hydrochloride

Pricing Availability   Qty
Description: Selective κ agonist
Chemical Name: trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Citations (9)
Reviews (4)
Literature (2)

Biological Activity for (±)-U-50488 hydrochloride

(±)-U-50488 hydrochloride is a selective κ-opioid agonist. At higher concentrations blocks Na+ channels.

(-)-enantiomer and (+)-enantiomer also available.

Technical Data for (±)-U-50488 hydrochloride

M. Wt 405.79
Formula C19H26Cl2N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 67197-96-0
PubChem ID 90479733
Smiles O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@H]1[C@H](N2CCCC2)CCCC1)C.O=C(CC6=CC(Cl)=C(Cl)C=C6)N([C@@H]4[C@@H](N5CCCC5)CCCC4)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-U-50488 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 10.14 25

Preparing Stock Solutions for (±)-U-50488 hydrochloride

The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.86 mL 49.29 mL 98.57 mL
1.25 mM 1.97 mL 9.86 mL 19.71 mL
2.5 mM 0.99 mL 4.93 mL 9.86 mL
12.5 mM 0.2 mL 0.99 mL 1.97 mL

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Product Datasheets for (±)-U-50488 hydrochloride

Certificate of Analysis / Product Datasheet
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References for (±)-U-50488 hydrochloride

References are publications that support the biological activity of the product.

Pao-Luh Tao et al (1994) U-50,488 blocks the development of mor. tolerance and dependence at a very low dose in guinea pigs. Eur.J.Pharmacol. 256 281 PMID: 8045272

Suarez-Roca and Maixner (1993) Activation of kappa opioid receptors by U-50488H and mor. enhances the release of substance P from rat trigeminal nucleus slices. J.Pharmacol.Exp.Ther. 264 648 PMID: 7679733

Pugsley et al (1992) Cardiovascular actions of the κ-agonist, U-50-488H, in the absence and presence of opioid receptor blockade. Br.J.Pharmacol. 105 521 PMID: 1320979

Su et al (1998) Blockade of the development of mor. tolerance by U-50,488, an AVP antagonist or MK 801 in the rat hippocampal slice. Br.J.Pharmacol. 123 625 PMID: 9517380

If you know of a relevant reference for (±)-U-50488 hydrochloride, please let us know.

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Keywords: (±)-U-50488 hydrochloride, (±)-U-50488 hydrochloride supplier, selective, agonists, κ-opioid, kappa-opioid, KOP, Receptors, OP2, Kappa, Opioid, 0495, Tocris Bioscience

9 Citations for (±)-U-50488 hydrochloride

Citations are publications that use Tocris products. Selected citations for (±)-U-50488 hydrochloride include:

Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife 6 e23785 PMID: 28402252

Li et al (2019) Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway. Int J Mol Med PMID: 31545485

Marchant et al (2010) Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinction. J Neurosci 30 14102 PMID: 20962231

Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360 eaao4927 PMID: 29930108

Do you know of a great paper that uses (±)-U-50488 hydrochloride from Tocris? Please let us know.

Reviews for (±)-U-50488 hydrochloride

Average Rating: 5 (Based on 4 Reviews.)

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Beta arrestin recruitment.
By Anonymous on 06/15/2021
Assay Type: In Vitro
Species: Human

Dose response curve of beta arrestin recruitment (Presto_Tango assay)

review image

JNK-dependent rescue of LTPGABA by acute norBNI.
By Anonymous on 03/18/2020
Assay Type: In Vivo
Species: Rat
Cell Line/Tissue: brain

U50488 (5 mg/kg) injection

PMID: 28402252
review image

Great product.
By Anonymous on 03/05/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: CHO

Successfully induced ERK1/2 phosphorylation in CHO cells expressing KOR.

review image

Behavioral effects of kappa agonists.
By Matthew Banks on 01/05/2018
Assay Type: In Vivo
Species: Rat

To evaluate the behavioral effects of unbiased and biased kappa agonists in animals

soluble in water up to 5.6 mg/mL

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.