(-)-U-50488 hydrochloride

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Cat.No. 0496 - (-)-U-50488 hydrochloride | C19H26Cl2N2O.HCl | CAS No. 114528-79-9
Description: Standard selective κ agonist. More active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

More active enantiomer of (±)-U-50488 (Cat. No. 0495). (+)-U-50488 hydrochloride (Cat. No. 0471) also available.

Compound Libraries

(-)-U-50488 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 405.79
Formula C19H26Cl2N2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 114528-79-9
PubChem ID 9931141
InChI Key KGMMGVIYOHGOKQ-APTPAJQOSA-N
Smiles O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.58 100
water 100

Preparing Stock Solutions

The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.32 mL 24.64 mL
5 mM 0.49 mL 2.46 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490

Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301

Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central dopamine (D2) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939

Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991


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Keywords: (-)-U-50488 hydrochloride, supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, Receptors, Tocris Bioscience

Citations for (-)-U-50488 hydrochloride

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