(-)-U-50488 hydrochloride

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Cat.No. 0496 - (-)-U-50488 hydrochloride | C19H26Cl2N2O.HCl | CAS No. 114528-79-9
Description: Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
Chemical Name: trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
Purity: ≥99% (HPLC)
Reviews (1)

Biological Activity

More active enantiomer of (±)-U-50488.

Racemate and (+)-enantiomer also available.

Compound Libraries

(-)-U-50488 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 405.79
Formula C19H26Cl2N2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 114528-79-9
PubChem ID 9931141
Smiles O=C(CC3=CC(Cl)=C(Cl)C=C3)N([C@@H]1[C@@H](N2CCCC2)CCCC1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water and to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490

Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301

Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D2) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939

Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991

If you know of a relevant reference for (-)-U-50488 hydrochloride, please let us know.

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Keywords: (-)-U-50488 hydrochloride, (-)-U-50488 hydrochloride supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, 0496, Tocris Bioscience

Citations for (-)-U-50488 hydrochloride

Citations are publications that use Tocris products.

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Reviews for (-)-U-50488 hydrochloride

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Behavior studies.
By Anonymous on 10/30/2017
Assay Type: In Vivo
Species: Mouse

We have used this product numerous times in animal behavior studies and with consistent results.

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