You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for (-)-U-50488 hydrochloride
(-)-U-50488 hydrochloride is a more active enantiomer of (±)-U-50488.
Technical Data for (-)-U-50488 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (-)-U-50488 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (-)-U-50488 hydrochloride
The following data is based on the product molecular weight 405.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.46 mL||12.32 mL||24.64 mL|
|5 mM||0.49 mL||2.46 mL||4.93 mL|
|10 mM||0.25 mL||1.23 mL||2.46 mL|
|50 mM||0.05 mL||0.25 mL||0.49 mL|
Product Datasheets for (-)-U-50488 hydrochloride
References for (-)-U-50488 hydrochloride
References are publications that support the biological activity of the product.
De Costa et al (1987) Synthesis and absolute configuration of optically pure enantiomers of a κ-opioid receptor selective antagonist. FEBS Lett. 223 335 PMID: 2822490
Morrone et al (1993) Withdrawal contractures of guinea-pig isolated ileum after acute activation of κ opioid receptors. Br.J.Pharmacol. 109 48 PMID: 8388301
Reddy and Bhargava (1993) Effect of chronic administration of U-50,488H, a kappa opioid receptor agonist on central DA (D2) receptors of the rat. Eur.J.Pharmacol. 235 23 PMID: 8390939
Zhu et al (1998) Agonist-induced desensitization and down-regulation of the human kappa opioid receptor expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 285 28 PMID: 9535991
If you know of a relevant reference for (-)-U-50488 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: (-)-U-50488 hydrochloride, (-)-U-50488 hydrochloride supplier, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, Kappa, Opioid, 0496, Tocris Bioscience
1 Citation for (-)-U-50488 hydrochloride
Citations are publications that use Tocris products. Selected citations for (-)-U-50488 hydrochloride include:
Pirino et al (2020) Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis Neuropharmacology 181 108341 PMID: 33011200
Do you know of a great paper that uses (-)-U-50488 hydrochloride from Tocris? Please let us know.
Reviews for (-)-U-50488 hydrochloride
Average Rating: 5 (Based on 2 Reviews.)
Have you used (-)-U-50488 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Dose response curve of beta arrestin recruitment
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.