Piceatannol

Pricing Availability   Qty
Cat.No. 1554 - Piceatannol | C14H12O4 | CAS No. 10083-24-6
Description: Inhibits TNF-induced NF-κB activation
Chemical Name: 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature
Pathways

Biological Activity

Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.

Technical Data

M. Wt 244.25
Formula C14H12O4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 10083-24-6
PubChem ID 667639
InChI Key CDRPUGZCRXZLFL-OWOJBTEDSA-N
Smiles OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 24.43 100
DMSO 24.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 244.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Ashikawa et al (2002) Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 169 6490 PMID: 12444159

Geahlen and McLaughlin (1989) Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 165 241 PMID: 2590224

Oliver et al (1994) Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 269 29697 PMID: 7961959

Potter et al (2002) The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 86 774 PMID: 11875742


If you know of a relevant reference for Piceatannol, please let us know.

View Related Products by Product Action

View all NF-κB and IκB Inhibitors

Keywords: Piceatannol, Piceatannol supplier, Syk, p56lck, kinase, inhibitors, inhibits, TNF-induced, NF-κB, NF-kappaB, NF-kB, activation, Kinases, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, Src, Kinase, NF-kB/IkB, 1554, Tocris Bioscience

8 Citations for Piceatannol

Citations are publications that use Tocris products. Selected citations for Piceatannol include:

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci 33 11206 PMID: 23825423

Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815

Verma et al (2015) Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33. J Neurosci 8 380 PMID: 25118166

Dierks et al (2010) The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res 70 6193 PMID: 20670954

Shin et al (2015) TH2 cells and their cytokines regulate formation and function of lymphatic vessels. Nat Commun 6 6196 PMID: 25648335

Bakema et al (2015) Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs. J Immunol 194 1856 PMID: 25582855

Farrand et al (2013) Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission. J Biol Chem 288 23740 PMID: 23833193


Do you know of a great paper that uses Piceatannol from Tocris? Please let us know.

Reviews for Piceatannol

There are currently no reviews for this product. Be the first to review Piceatannol and earn rewards!

Have you used Piceatannol?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for Piceatannol

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.