Oct 4 activator; enhances iPSC reprogramming four-fold and accelerates the appearance of iPSC colonies in combination with 4F (Oct4, Sox2, c-Myc and Klf4). Also induces cardiomyocyte-like cells from human fibroblasts, as part of the 9C cocktail (CHIR99021, A83-01, BIX01294, AS83541, SC1, Y27632, SU 16f, JNJ10198409 and OAC-2)
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 236.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.23 mL||21.16 mL||42.32 mL|
|5 mM||0.85 mL||4.23 mL||8.46 mL|
|10 mM||0.42 mL||2.12 mL||4.23 mL|
|50 mM||0.08 mL||0.42 mL||0.85 mL|
References are publications that support the products' biological activity.
Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.USA. 109 20853 PMID: 23213213
Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239
If you know of a relevant reference for OAC-2, please let us know.
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Keywords: OAC-2, supplier, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, inducible, pluripotent, stem, cells, Reprogramming, Other, Transcription, Factors, Reprogramming, Tocris Bioscience
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Literature in this Area
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.