OAC-2

Pricing Availability Delivery Time Qty
Cat.No. 6066 - OAC-2 | C15H12N2O | CAS No. 6019-39-2
Description: Oct4 activator; enhances iPSC reprogramming efficiency
Chemical Name: N-(1H-Indol-5-yl)benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Protocols (1)
Literature

Biological Activity

Oct 4 activator; enhances iPSC reprogramming four-fold and accelerates the appearance of iPSC colonies in combination with 4F (Oct4, Sox2, c-Myc and Klf4). Also induces cardiomyocyte-like cells from human fibroblasts, as part of the 9C cocktail (CHIR99021, A83-01, BIX01294, AS83541, SC1, Y27632, SU 16f, JNJ10198409 and OAC-2)

Technical Data

M. Wt 236.27
Formula C15H12N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 6019-39-2
PubChem ID 2814138
InChI Key JCAFGYWSIWYMOX-UHFFFAOYSA-N
Smiles O=C(C1=CC=CC=C1)NC2=CC=C3C(C=CN3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 23.63 100
DMSO 23.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.23 mL 21.16 mL 42.32 mL
5 mM 0.85 mL 4.23 mL 8.46 mL
10 mM 0.42 mL 2.12 mL 4.23 mL
50 mM 0.08 mL 0.42 mL 0.85 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Li et al (2012) Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc.Natl.Acad.Sci.USA. 109 20853 PMID: 23213213

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 1216 PMID: 27127239


If you know of a relevant reference for OAC-2, please let us know.

Keywords: OAC-2, supplier, iPSCs, reprogramming, factors, Oct4, activators, Sox2, Nanog, inducers, enhances, accelerates, inducible, pluripotent, stem, cells, Reprogramming, Other, Transcription, Factors, Reprogramming, Tocris Bioscience

Citations for OAC-2

Citations are publications that use Tocris products.

Currently there are no citations for OAC-2. Do you know of a great paper that uses OAC-2 from Tocris? If so please let us know.

Reviews for OAC-2

There are currently no reviews for this product. Be the first to review OAC-2 and earn rewards!

Have you used OAC-2?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Protocols for OAC-2

The following protocol features additional information for the use of OAC-2 (Cat. No. 6066).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Stem Cells

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.