Neuropathiazol

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Cat.No. 5186 - Neuropathiazol | C19H18N2O2S | CAS No. 880090-88-0
Description: Selective inducer of neuronal differentiation in hippocampal neural progenitors
Chemical Name: Ethyl 4-[methyl-(2-phenyl-1,3-thiazol-4-yl)amino]benzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inducer of neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs). Selectively suppresses astrocyte differentiation when induced by LIF, BMP2 and FBS compared to retinoic acid. Enhances maturation of NPC derived neurons.

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Technical Data

M. Wt 338.42
Formula C19H18N2O2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 880090-88-0
PubChem ID 11667240
InChI Key MGKYEWWFHSESJN-UHFFFAOYSA-N
Smiles O=C(OCC)C1=CC=C(N(C2=CSC(C3=CC=CC=C3)=N2)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.84 100
ethanol 6.77 20

Preparing Stock Solutions

The following data is based on the product molecular weight 338.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.77 mL 29.55 mL
5 mM 0.59 mL 2.95 mL 5.91 mL
10 mM 0.3 mL 1.48 mL 2.95 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Warashina et al (2006) A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem. Int. Ed. Engl. 45 591 PMID: 16323231


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Keywords: Selective inducers neuronal differentiation neural progenitor cells NPCs stem cells Neural Stem Cells

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Literature in this Area

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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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