Discontinued Product

MNS (Cat. No. 2877) has been withdrawn from sale for commercial reasons.
Description: Selective inhibitor of Src and Syk
Chemical Name: 3,4-Methylenedioxy-β-nitrostyrene
Purity: ≥99% (HPLC)

Biological Activity for MNS

MNS is a selective inhibitor of Src and Syk tyrosine kinases. Inhibits thrombin-induced platelet aggregation via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism. Also inhibits inflammasome activation.

Technical Data for MNS

M. Wt 193.16
Formula C9H7NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1485-00-3
PubChem ID 672296
Smiles O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for MNS

References are publications that support the biological activity of the product.

Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624

Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492

He et al (2014) 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J.Biol.Chem. 289 1142 PMID: 24265316

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Keywords: MNS, MNS supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Kinase, Cell, Integrins, Inflammasomes, 2877, Tocris Bioscience

Citations for MNS

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Currently there are no citations for MNS.

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