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Cat.No. 2877 - MNS | C9H7NO4 | CAS No. 1485-00-3
Description: Selective inhibitor of Src and Syk
Chemical Name: 3,4-Methylenedioxy-β-nitrostyrene
Purity: ≥99% (HPLC)

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism.

Technical Data

M. Wt 193.16
Formula C9H7NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1485-00-3
PubChem ID 672296
Smiles O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 19.32 100
ethanol 0.97 5

Preparing Stock Solutions

The following data is based on the product molecular weight 193.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.18 mL 25.89 mL 51.77 mL
5 mM 1.04 mL 5.18 mL 10.35 mL
10 mM 0.52 mL 2.59 mL 5.18 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624

Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492

If you know of a relevant reference for MNS, please let us know.

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View all Src Kinase Inhibitors

Keywords: MNS, supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Src, Kinases, Syk, Kinase, Cell, Adhesion, Molecules, Integrins, Src, Kinases, Tocris Bioscience

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