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Selective inhibitor of Src and Syk tyrosine kinases. Inhibits thrombin-induced platelet aggregation via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism. Also inhibits inflammasome activation.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 193.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.18 mL||25.89 mL||51.77 mL|
|5 mM||1.04 mL||5.18 mL||10.35 mL|
|10 mM||0.52 mL||2.59 mL||5.18 mL|
|50 mM||0.1 mL||0.52 mL||1.04 mL|
References are publications that support the biological activity of the product.
Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624
Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492
He et al (2014) 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J.Biol.Chem. 289 1142 PMID: 24265316
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Keywords: MNS, MNS supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Kinase, Cell, Integrins, Inflammasomes, 2877, Tocris Bioscience
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