MNS

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Cat.No. 2877 - MNS | C9H7NO4 | CAS No. 1485-00-3
Description: Selective inhibitor of Src and Syk
Chemical Name: 3,4-Methylenedioxy-β-nitrostyrene
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism.

Technical Data

M. Wt 193.16
Formula C9H7NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1485-00-3
PubChem ID 672296
InChI Key KFLWBZPSJQPRDD-ONEGZZNKSA-N
Smiles O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.32 100
ethanol 0.97 5

Preparing Stock Solutions

The following data is based on the product molecular weight 193.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.18 mL 25.89 mL 51.77 mL
5 mM 1.04 mL 5.18 mL 10.35 mL
10 mM 0.52 mL 2.59 mL 5.18 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624

Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492


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Keywords: MNS, supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Src, Kinases, Syk, Kinase, Cell, Adhesion, Molecules, Integrins, Src, Kinases, Tocris Bioscience

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