ML 141

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Cat.No. 4266 - ML 141 | C22H21N3O3S | CAS No. 71203-35-5
Description: Selective inhibitor of Cdc42 Rho family GTPase
Alternative Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Compound Libraries

ML 141 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 407.49
Formula C22H21N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 71203-35-5
PubChem ID 2950007
InChI Key QBNZBMVRFYREHK-UHFFFAOYSA-N
Smiles COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.54 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196 PMID: 21433396

Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub PMID: 23382385


If you know of a relevant reference for ML 141, please let us know.

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View all GTPase Inhibitors

Keywords: ML 141, supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, CID, 2950007, GTPase, G, Proteins, (Small), GTPase, Tocris Bioscience

6 Citations for ML 141

Citations are publications that use Tocris products. Selected citations for ML 141 include:

Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502 PMID: 23524265

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978

Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673 PMID: 25878109

Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238 PMID: 25527498

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83 PMID: 24760984

Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113 PMID: 23064517


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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New Product Guide (Spring/Summer 2017)

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