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ML 141

Cat. No. 4266 8 Citations Submit a Review Datasheet / COA / SDS
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Cat.No. 4266 - ML 141 | C22H21N3O3S | CAS No. 71203-35-5
Description: Selective Cdc42 Rho family inhibitor
Alternative Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Compound Libraries

ML 141 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 407.49
Formula C22H21N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 71203-35-5
PubChem ID 2950007
InChI Key QBNZBMVRFYREHK-UHFFFAOYSA-N
Smiles COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.75 100

Preparing Stock Solutions

The following data is based on the product molecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.54 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196 PMID: 21433396

Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub PMID: 23382385

If you know of a relevant reference for ML 141, please let us know.

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Keywords: ML 141, ML 141 supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, CID, 2950007, 4266, Tocris Bioscience

8 Citations for ML 141

Citations are publications that use Tocris products. Selected citations for ML 141 include:

Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673 PMID: 25878109

Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238 PMID: 25527498

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978

Najjar et al (2016) Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog 12 e1005922 PMID: 27683250

Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403

Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502 PMID: 23524265

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83 PMID: 24760984

Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113 PMID: 23064517

Do you know of a great paper that uses ML 141 from Tocris? Please let us know.

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Literature in this Area

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