ML 141

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Description: Selective Cdc42 Rho family inhibitor
Alternative Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥99% (HPLC)
Citations (23)

Biological Activity for ML 141

ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.

Compound Libraries for ML 141

ML 141 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 141

M. Wt 407.49
Formula C22H21N3O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 71203-35-5
PubChem ID 2950007
Smiles COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 141

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.75 100

Preparing Stock Solutions for ML 141

The following data is based on the product molecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.27 mL 24.54 mL
5 mM 0.49 mL 2.45 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets for ML 141

Certificate of Analysis / Product Datasheet
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References for ML 141

References are publications that support the biological activity of the product.

Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196 PMID: 21433396

Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub PMID: 23382385

If you know of a relevant reference for ML 141, please let us know.

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Keywords: ML 141, ML 141 supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, CID, 2950007, 4266, Tocris Bioscience

23 Citations for ML 141

Citations are publications that use Tocris products. Selected citations for ML 141 include:

Wenming et al (2021) Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. Commun Biol 4 1239 PMID: 34716403

Donatella et al (2021) Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction. J Cell Biol 220 PMID: 33566069

Shiro et al (2021) FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells. iScience 24 102994 PMID: 34485872

Nibaldo C et al (2021) Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons. J Neurochem 158 673-693 PMID: 34107066

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978

Xing et al (2016) GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell 27 3828 PMID: 27708138

Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673 PMID: 25878109

Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238 PMID: 25527498

Sepúlveda-Ramírez et al (2018) Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol 437 140 PMID: 29555242

Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463

Thottacherry et al (2018) Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nat Commun 9 4217 PMID: 30310066

Pontremoli et al (2018) Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells. Sci Rep 8 16671 PMID: 30420710

Sara et al (2022) Caveolae couple mechanical stress to integrin recycling and activation. Elife 11 PMID: 36264062

Klara I et al (2022) Local changes in microtubule network mobility instruct neuronal polarization and axon specification. Sci Adv 8 eabo2343 PMID: 36332030

Li et al (2019) A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases. iScience 12 232 PMID: 30711747

Raymond P et al (2022) Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad 8 100307 PMID: 36514715

Patricio I et al (2022) The Process of Filopodia Induction during HPV Infection. Viruses 14 PMID: 35746622

Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113 PMID: 23064517

El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83 PMID: 24760984

Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403

Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502 PMID: 23524265

Najjar et al (2016) Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog 12 e1005922 PMID: 27683250

Hak et al (2018) FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol 20 1023 PMID: 30061681

Do you know of a great paper that uses ML 141 from Tocris? Please let us know.

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