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Submit ReviewML 141
Description: Selective Cdc42 Rho family inhibitor
Alternative Names: CID 2950007
Chemical Name: 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]benzenesulfonamide
Purity: ≥99% (HPLC)
Biological Activity for ML 141
ML 141 is an allosteric inhibitor of Cdc42 GTPase (EC50 = 2.1 μM). Selective for Cdc42 over other members of the Rho GTPase family including Rac1, Rab2 and Rab7. Inhibits ovarian cancer cell migration in vitro.
Compound Libraries for ML 141
ML 141 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for ML 141
| M. Wt | 407.49 |
| Formula | C22H21N3O3S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 71203-35-5 |
| PubChem ID | 2950007 |
| InChI Key | QBNZBMVRFYREHK-UHFFFAOYSA-N |
| Smiles | COC(C=C4)=CC=C4C1CC(C3=CC=CC=C3)=NN1C2=CC=C(S(=O)(N)=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ML 141
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.75 | 100 |
Preparing Stock Solutions for ML 141
The following data is based on the product molecular weight 407.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.27 mL | 24.54 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for ML 141
References for ML 141
References are publications that support the biological activity of the product.
Surviladze et al (2010) A potent and selective inhibitor of Cdc42 GTPase. Probe Reports from the Molecular Libraries Program NBK5196 PMID: 21433396
Hong et al (2013) Characterization of a Cdc42 GTPase Inhibitor and its Use as a Molecular Probe. J.Biol.Chem. Epub PMID: 23382385
If you know of a relevant reference for ML 141, please let us know.
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Keywords: ML 141, ML 141 supplier, ML141, CID2950007, inhibits, cdc42, Rho, GTPase, inhibitor, inhibitors, CID, 2950007, 4266, Tocris Bioscience
15 Citations for ML 141
Citations are publications that use Tocris products. Selected citations for ML 141 include:
Hak et al (2018) FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol 20 1023 PMID: 30061681
Sepúlveda-Ramírez et al (2018) Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo. Dev Biol 437 140 PMID: 29555242
Najjar et al (2016) Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread. PLoS Pathog 12 e1005922 PMID: 27683250
Lomakin et al (2015) Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol 17 1435 PMID: 26414403
Tseng et al (2012) Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Am J Physiol Cell Physiol 9 1113 PMID: 23064517
Mues et al (2015) Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol 89 6673 PMID: 25878109
Sumida and Yamada (2015) Rho GTPases and the downstream effectors actin-related protein 2/3 (Arp2/3) complex and myosin II induce membrane fusion at self-contacts. J Biol Chem 290 3238 PMID: 25527498
Li et al (2019) A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases. iScience 12 232 PMID: 30711747
McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978
Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463
Thottacherry et al (2018) Mechanochemical feedback control of dynamin independent endocytosis modulates membrane tension in adherent cells. Nat Commun 9 4217 PMID: 30310066
Pontremoli et al (2018) Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells. Sci Rep 8 16671 PMID: 30420710
Wan et al (2013) Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts. Biochem Biophys Res Commun 433 502 PMID: 23524265
Xing et al (2016) GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell 27 3828 PMID: 27708138
El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Nat Commun 307 C83 PMID: 24760984
Do you know of a great paper that uses ML 141 from Tocris? Please let us know.
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