Methylnaltrexone bromide

Pricing Availability   Qty
Description: μ antagonist; peripherally restricted
Chemical Name: 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Methylnaltrexone bromide

Methylnaltrexone bromide is a peripherally restricted μ-opioid antagonist. Antagonizes the effects of morphine (Cat. No. 5158) on contraction of isolated guinea pig ileum. Quaternary derivative of naltrexone (Cat. No. 0677).

Technical Data for Methylnaltrexone bromide

M. Wt 436.34
Formula C21H26BrNO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 73232-52-7
PubChem ID 5361917
Smiles O=C1[C@H]2C34C5=C(O2)C(O)=CC=C5CC([N+](CC6CC6)(C)CC4)[C@]3(O)CC1.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Methylnaltrexone bromide

Solvent Max Conc. mg/mL Max Conc. mM
water 43.63 100
DMSO 43.63 100

Preparing Stock Solutions for Methylnaltrexone bromide

The following data is based on the product molecular weight 436.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.46 mL 22.92 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets for Methylnaltrexone bromide

References for Methylnaltrexone bromide

References are publications that support the biological activity of the product.

Valentino et al (1981) Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists. J.Pharmacol.Exp.Ther. 217 652 PMID: 6262493

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Citations for Methylnaltrexone bromide

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