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Submit ReviewMethylnaltrexone bromide
Description: μ antagonist; peripherally restricted
Chemical Name: 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide
Purity: ≥98% (HPLC)
Biological Activity for Methylnaltrexone bromide
Methylnaltrexone bromide is a peripherally restricted μ-opioid antagonist. Antagonizes the effects of morphine (Cat. No. 5158) on contraction of isolated guinea pig ileum. Quaternary derivative of naltrexone (Cat. No. 0677).
Technical Data for Methylnaltrexone bromide
| M. Wt | 436.34 |
| Formula | C21H26BrNO4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 73232-52-7 |
| PubChem ID | 5361917 |
| InChI Key | IFGIYSGOEZJNBE-KNLJMPJLSA-N |
| Smiles | O=C1[C@H]2C34C5=C(O2)C(O)=CC=C5CC([N+](CC6CC6)(C)CC4)[C@]3(O)CC1.[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Methylnaltrexone bromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 43.63 | 100 | |
| DMSO | 43.63 | 100 |
Preparing Stock Solutions for Methylnaltrexone bromide
The following data is based on the product molecular weight 436.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.46 mL | 22.92 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for Methylnaltrexone bromide
References for Methylnaltrexone bromide
References are publications that support the biological activity of the product.
Valentino et al (1981) Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists. J.Pharmacol.Exp.Ther. 217 652 PMID: 6262493
If you know of a relevant reference for Methylnaltrexone bromide, please let us know.
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