Morphine hydrochloride

Pricing Availability   Qty
Description: Narcotic opioid analgesic
Chemical Name: 7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol hydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Reviews (1)
Literature (2)

Biological Activity for Morphine hydrochloride

Morphine hydrochloride is a narcotic opioid analgesic.

Technical Data for Morphine hydrochloride

M. Wt 321.8
Formula C17H19NO3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 52-26-6
PubChem ID 5464110
Smiles O[C@@H]3[C@H]5[C@]24C1=C(O5)C(O)=CC=C1C[C@@H](N(C)CC4)[C@@]([H])2C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Morphine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 16.09 50

Preparing Stock Solutions for Morphine hydrochloride

The following data is based on the product molecular weight 321.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.22 mL 31.08 mL 62.15 mL
2.5 mM 1.24 mL 6.22 mL 12.43 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
25 mM 0.12 mL 0.62 mL 1.24 mL

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Product Datasheets for Morphine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Morphine hydrochloride

References are publications that support the biological activity of the product.

Merck Index 12 1074

If you know of a relevant reference for Morphine hydrochloride, please let us know.

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Keywords: Morphine hydrochloride, Morphine hydrochloride supplier, opioid, receptors, analgesic, Miscellaneous/Non-selective, Opioids, 5158, Tocris Bioscience

4 Citations for Morphine hydrochloride

Citations are publications that use Tocris products. Selected citations for Morphine hydrochloride include:

Prather et al (2013) CB1 and CB2 receptors are novel molecular targets for tamox. and 4OH-Tamoxifen. Biochem Biophys Res Commun 441 339 PMID: 24148245

Rajasekaran et al (2013) Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol Appl Pharmacol 269 100 PMID: 23537664

Mohammad et al (2021) Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action. Res Pharm Sci 16 203-216 PMID: 34084207

Jose A et al (2021) An endogenous opioid circuit determines state-dependent reward consumption. Nature 598 646-651 PMID: 34646022

Do you know of a great paper that uses Morphine hydrochloride from Tocris? Please let us know.

Reviews for Morphine hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Morphine inhibits AITC-induced p42/44 phosphorylation in brain.
By Christopher Trummer on 10/15/2018
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: Brain

Saline or morphine (10 mg/kg, s.c.) was injected 1 h prior to intrarectal instillation of peanut oil (Veh) or AITC 2% (v/v) in mice. Phosphorylation of p42/44 was analysed in spinal cord (Sc), thalamus (Th), hypothalamus (Hth), amygdala (Amy), and prefrontal cortex (Pfc) lysates using Western blot. Morphine significantly inhibited AITC-induced pp42/44 expression (shown in Image).

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.