Naltrexone hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0677 - Naltrexone hydrochloride | C20H23NO4.HCl | CAS No. 16676-29-2
Description: Broad spectrum opioid antagonist
Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Opioid antagonist.

Technical Data

M. Wt 377.87
Formula C20H23NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 16676-29-2
PubChem ID 11957643
InChI Key RHBRMCOKKKZVRY-OGWSAYKTSA-N
Smiles O=C3[C@H]5C24C1=C(O5)C(O)=CC=C1CC(N(CC6CC6)CC4)[C@@](O)2CC3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.46 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gold et al (1982) Naltrexone, opiate addiction, and endorphins. Med.Res.Rev. 2 211 PMID: 6289026

Tempel et al (1982) Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment. Life Sci. 31 1401 PMID: 6292636

Zukin et al (1982) Naltrexone-induced opiate receptor supersensitivity. Brain Res. 245 285 PMID: 6289965


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Keywords: Naltrexone hydrochloride, supplier, Broad, spectrum, antagonists, Opioids, Receptors, Miscellaneous/Non-selective, Opioids, Tocris Bioscience

5 Citations for Naltrexone hydrochloride

Citations are publications that use Tocris products. Selected citations for Naltrexone hydrochloride include:

Leskelä et al (2012) Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem 287 5008 PMID: 22184124

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

Chung et al (2010) Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice. Hum Mol Genet 11 847 PMID: 20418186

Tumati et al (2009) Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner. J Pain 330 810 PMID: 19491327

Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511


Do you know of a great paper that uses Naltrexone hydrochloride from Tocris? If so please let us know.

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Pathways for Naltrexone hydrochloride

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