Naltrexone hydrochloride

Pricing Availability   Qty
Description: Non-selective opioid antagonist
Chemical Name: (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydromorphinan-6-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews
Literature (2)

Biological Activity for Naltrexone hydrochloride

Naltrexone hydrochloride is an opioid antagonist.

Technical Data for Naltrexone hydrochloride

M. Wt 377.87
Formula C20H23NO4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 16676-29-2
PubChem ID 11957643
InChI Key RHBRMCOKKKZVRY-ITLPAZOVSA-N
Smiles Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Naltrexone hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 37.79 100

Preparing Stock Solutions for Naltrexone hydrochloride

The following data is based on the product molecular weight 377.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.46 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for Naltrexone hydrochloride

Certificate of Analysis / Product Datasheet
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References for Naltrexone hydrochloride

References are publications that support the biological activity of the product.

Gold et al (1982) Naltrexone, opiate addiction, and endorphins. Med.Res.Rev. 2 211 PMID: 6289026

Tempel et al (1982) Supersensitivity of brain opiate receptor subtypes after chronic naltr. treatment. Life Sci. 31 1401 PMID: 6292636

Zukin et al (1982) Naltrexone-induced opiate receptor supersensitivity. Brain Res. 245 285 PMID: 6289965


If you know of a relevant reference for Naltrexone hydrochloride, please let us know.

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Keywords: Naltrexone hydrochloride, Naltrexone hydrochloride supplier, Broad, spectrum, antagonists, Opioids, Receptors, Miscellaneous/Non-selective, 0677, Tocris Bioscience

9 Citations for Naltrexone hydrochloride

Citations are publications that use Tocris products. Selected citations for Naltrexone hydrochloride include:

Smith et al (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A 113 13893 PMID: 27849613

Leskelä et al (2012) Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem 287 5008 PMID: 22184124

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

Chung et al (2010) Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice. Hum Mol Genet 11 847 PMID: 20418186


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.