Lercanidipine hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2959 - Lercanidipine hydrochloride | C36H41N3O6.HCl | CAS No. 132866-11-6
Description: Ca2+ channel blocker (L-type)
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine (Cat. No. 2960). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive.

Technical Data

M. Wt 648.19
Formula C36H41N3O6.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 132866-11-6
PubChem ID 157917
InChI Key WMFYOYKPJLRMJI-UHFFFAOYSA-N
Smiles CC1=C(C(OC(C)(C)CN(C)CCC(C4=CC=CC=C4)C3=CC=CC=C3)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OC)=O)=C(C)N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.82 100
ethanol 6.48 10

Preparing Stock Solutions

The following data is based on the product molecular weight 648.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.54 mL 7.71 mL 15.43 mL
5 mM 0.31 mL 1.54 mL 3.09 mL
10 mM 0.15 mL 0.77 mL 1.54 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bang et al (2003) Lercanidipine. A review of its efficacy in the management of hypertension. Drugs 63 2449 PMID: 14609358

Wirtz and Herzig (2004) Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine. Br.J.Pharmacol. 142 275 PMID: 15155536

Sironi et al (1996) Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneim.Forsch. 46 152 PMID:


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Keywords: Lercanidipine hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Voltage-gated, Calcium, Channels, Voltage-gated, Calcium, Channels, Tocris Bioscience

Citations for Lercanidipine hydrochloride

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