Discontinued Product

Felodipine (Cat. No. 2960) has been withdrawn from sale for commercial reasons.
Description: CaV1.x blocker
Chemical Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Purity: ≥98% (HPLC)
Reviews (1)

Biological Activity for Felodipine

Felodipine is a L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Compound Libraries for Felodipine

Felodipine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Felodipine

M. Wt 384.25
Formula C18H19Cl2NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 72509-76-3
PubChem ID 3333
Smiles ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Felodipine

References are publications that support the biological activity of the product.

Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11 PMID: 1693715

Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464 PMID: 10525060

Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241 PMID: 15725949

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Keywords: Felodipine, Felodipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Cav1.x, 2960, Tocris Bioscience

Citations for Felodipine

Citations are publications that use Tocris products.

Currently there are no citations for Felodipine.

Reviews for Felodipine

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Felodipine used on Cav1.2 channels.
By Anonymous on 02/04/2019
Species: Human

Felodipine used on Cav1.2 channels to see the effect on blocking with increasing concentration and the underlying mechanism involved.

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