Felodipine

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Cat.No. 2960 - Felodipine | C18H19Cl2NO4 | CAS No. 72509-76-3
Description: CaV1.x blocker
Chemical Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Compound Libraries

Felodipine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 384.25
Formula C18H19Cl2NO4
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 72509-76-3
PubChem ID 3333
InChI Key RZTAMFZIAATZDJ-UHFFFAOYSA-N
Smiles ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.42 100
ethanol 38.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 384.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.6 mL 13.01 mL 26.02 mL
5 mM 0.52 mL 2.6 mL 5.2 mL
10 mM 0.26 mL 1.3 mL 2.6 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11 PMID: 1693715

Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464 PMID: 10525060

Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241 PMID: 15725949


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Keywords: Felodipine, Felodipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Cav1.x, 2960, Tocris Bioscience

Citations for Felodipine

Citations are publications that use Tocris products.

Currently there are no citations for Felodipine. Do you know of a great paper that uses Felodipine from Tocris? Please let us know.

Reviews for Felodipine

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Felodipine used on Cav1.2 channels.
By Anonymous on 02/04/2019
Species: Human

Felodipine used on Cav1.2 channels to see the effect on blocking with increasing concentration and the underlying mechanism involved.

review image

Literature in this Area

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