Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog IHR 1 also available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1174.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.26 mL||8.51 mL|
|5 mM||0.17 mL||0.85 mL||1.7 mL|
|10 mM||0.09 mL||0.43 mL||0.85 mL|
|50 mM||0.02 mL||0.09 mL||0.17 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239
If you know of a relevant reference for IHR-Cy3, please let us know.
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Keywords: Potent fluorescent Smo antagonists antagonism hedgehog signalling signaling inhibitors inhibits response smoothened receptors IHR1 Smoothened Receptors
Citations for IHR-Cy3
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