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Cat.No. 5561 - IHR-Cy3 | C58H63Cl3N6O10S2
Description: Potent fluorescent Smo antagonist
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity: ≥95% (HPLC)
Literature (3)

Biological Activity for IHR-Cy3

IHR-Cy3 is a potent fluorescent Smo antagonist (IC50 = 100 nM).

Non-fluorescent analog also available.

Technical Data for IHR-Cy3

M. Wt 1174.64
Formula C58H63Cl3N6O10S2
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 122705984
Smiles ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for IHR-Cy3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.87 5

Preparing Stock Solutions for IHR-Cy3

The following data is based on the product molecular weight 1174.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 17.03 mL 85.13 mL 170.26 mL
0.25 mM 3.41 mL 17.03 mL 34.05 mL
0.5 mM 1.7 mL 8.51 mL 17.03 mL
2.5 mM 0.34 mL 1.7 mL 3.41 mL

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References for IHR-Cy3

References are publications that support the biological activity of the product.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239

If you know of a relevant reference for IHR-Cy3, please let us know.

Keywords: IHR-Cy3, IHR-Cy3 supplier, Potent, fluorescent, Smo, antagonists, antagonism, hedgehog, signalling, signaling, inhibitors, inhibits, response, smoothened, receptors, IHR1, Smoothened, Receptors, Hedgehog, Signaling, Fluorescent, Receptor, Probes, 5561, Tocris Bioscience

Citations for IHR-Cy3

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Currently there are no citations for IHR-Cy3. Do you know of a great paper that uses IHR-Cy3 from Tocris? Please let us know.

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Literature in this Area

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