IHR-Cy3

Pricing Availability   Qty
Cat.No. 5561 - IHR-Cy3 | C58H63Cl3N6O10S2
Description: Potent fluorescent Smo antagonist
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent fluorescent Smo antagonist (IC50 = 100 nM).

Non-fluorescent analog also available.

Technical Data

M. Wt 1174.64
Formula C58H63Cl3N6O10S2
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 122705984
InChI Key KBLRMHCNXCHIQG-UHFFFAOYSA-N
Smiles ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.87 5

Preparing Stock Solutions

The following data is based on the product molecular weight 1174.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 17.03 mL 85.13 mL 170.26 mL
0.25 mM 3.41 mL 17.03 mL 34.05 mL
0.5 mM 1.7 mL 8.51 mL 17.03 mL
2.5 mM 0.34 mL 1.7 mL 3.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239


If you know of a relevant reference for IHR-Cy3, please let us know.

Keywords: IHR-Cy3, IHR-Cy3 supplier, Potent, fluorescent, Smo, antagonists, antagonism, hedgehog, signalling, signaling, inhibitors, inhibits, response, smoothened, receptors, IHR1, Smoothened, Receptors, Hedgehog, Signaling, Fluorescent, Receptor, Probes, 5561, Tocris Bioscience

Citations for IHR-Cy3

Citations are publications that use Tocris products.

Currently there are no citations for IHR-Cy3. Do you know of a great paper that uses IHR-Cy3 from Tocris? Please let us know.

Reviews for IHR-Cy3

There are currently no reviews for this product. Be the first to review IHR-Cy3 and earn rewards!

Have you used IHR-Cy3?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Enabling Research By Provision of Chemical Tools

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.