IHR-Cy3

Pricing Availability   Qty
Cat.No. 5561 - IHR-Cy3 | C58H63Cl3N6O10S2
Description: Potent fluorescent Smo antagonist
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent fluorescent Smo antagonist (IC50 = 100 nM).

Non-fluorescent analog also available.

Technical Data

M. Wt 1174.64
Formula C58H63Cl3N6O10S2
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 122705984
InChI Key KBLRMHCNXCHIQG-UHFFFAOYSA-N
Smiles ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.87 5

Preparing Stock Solutions

The following data is based on the product molecular weight 1174.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 17.03 mL 85.13 mL 170.26 mL
0.25 mM 3.41 mL 17.03 mL 34.05 mL
0.5 mM 1.7 mL 8.51 mL 17.03 mL
2.5 mM 0.34 mL 1.7 mL 3.41 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239


If you know of a relevant reference for IHR-Cy3, please let us know.

View Related Products by Product Action

View all Smoothened Receptor Antagonists

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Citations for IHR-Cy3

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Literature in this Area

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