IHR-Cy3

Pricing Availability Delivery Time Qty
Cat.No. 5561 - IHR-Cy3 | C58H63Cl3N6O10S2
Description: Potent fluorescent Smo antagonist
Chemical Name: (2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog IHR 1 also available.

Technical Data

M. Wt 1174.64
Formula C58H63Cl3N6O10S2
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 122705984
InChI Key KBLRMHCNXCHIQG-UHFFFAOYSA-N
Smiles ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.87 5

Preparing Stock Solutions

The following data is based on the product molecular weight 1174.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.85 mL 4.26 mL 8.51 mL
5 mM 0.17 mL 0.85 mL 1.7 mL
10 mM 0.09 mL 0.43 mL 0.85 mL
50 mM 0.02 mL 0.09 mL 0.17 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID: 25484239


If you know of a relevant reference for IHR-Cy3, please let us know.

View Related Products by Product Action

View all Smoothened Receptor Antagonists

Keywords: Potent fluorescent Smo antagonists antagonism hedgehog signalling signaling inhibitors inhibits response smoothened receptors IHR1 Smoothened Receptors

Citations for IHR-Cy3

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for IHR-Cy3

Protocols

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