ICI 199,441 hydrochloride

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Cat.No. 0778 - ICI 199,441 hydrochloride | C21H24Cl2N2O.HCl | CAS No. 115199-84-3
Description: Potent κ agonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

ICI 199,441 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 427.8
Formula C21H24Cl2N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 115199-84-3
PubChem ID 3082717
InChI Key VFLWVWZSDBTGQJ-VEIFNGETSA-N
Smiles ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol

References

References are publications that support the biological activity of the product.

Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636

Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918


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