You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
ICI 199,441 hydrochloride
Biological Activity for ICI 199,441 hydrochloride
ICI 199,441 hydrochloride is a highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Sold with the permission of AstraZeneca UK Ltd.
Compound Libraries for ICI 199,441 hydrochloride
Technical Data for ICI 199,441 hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ICI 199,441 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ICI 199,441 hydrochloride
The following data is based on the product molecular weight 427.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.69 mL||23.38 mL|
|5 mM||0.47 mL||2.34 mL||4.68 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
Product Datasheets for ICI 199,441 hydrochloride
References for ICI 199,441 hydrochloride
References are publications that support the biological activity of the product.
Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636
Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918
If you know of a relevant reference for ICI 199,441 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: ICI 199,441 hydrochloride, ICI 199,441 hydrochloride supplier, Potent, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, ICI199441, hydrochloride, AstraZeneca, Kappa, Opioid, 0778, Tocris Bioscience
Citations for ICI 199,441 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for ICI 199,441 hydrochloride. Do you know of a great paper that uses ICI 199,441 hydrochloride from Tocris? Please let us know.
Reviews for ICI 199,441 hydrochloride
There are currently no reviews for this product. Be the first to review ICI 199,441 hydrochloride and earn rewards!
Have you used ICI 199,441 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.