ICI 199,441 hydrochloride

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Cat.No. 0778 - ICI 199,441 hydrochloride | C21H24Cl2N2O.HCl | CAS No. 115199-84-3
Description: Potent κ agonist
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries

ICI 199,441 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 427.8
Formula C21H24Cl2N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 115199-84-3
PubChem ID 3082717
InChI Key VFLWVWZSDBTGQJ-VEIFNGETSA-N
Smiles ClC1=C(Cl)C=C(CC(N([C@@]([H])([C@]3=CC=CC=C3)CN2CCCC2)C)=O)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 50 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 427.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.69 mL 23.38 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636

Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918


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Keywords: Potent κ-opioid kappa-opioid agonists KOP Receptors OP2 ICI199441 hydrochloride AstraZeneca Kappa Opioid Receptors

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