ICI 199,441 hydrochloride
Highly potent κ agonist, 146-fold more active than U-50488 (Cat. No. 0495) in vitro.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO and to 50 mM in ethanol|
Preparing Stock Solutions
The following data is based on the product molecular weight 427.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.69 mL||23.38 mL|
|5 mM||0.47 mL||2.34 mL||4.68 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Barlow et al (1991) Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]acetamides: a novel series of potent and selective κ-opioid agonists. J.Med.Chem. 34 3149 PMID: 1659636
Costello et al (1991) 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted-ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid κ agonists. J.Med.Chem. 34 181 PMID: 1846918
If you know of a relevant reference for ICI 199,441 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Potent κ-opioid kappa-opioid agonists KOP Receptors OP2 ICI199441 hydrochloride AstraZeneca Kappa Opioid Receptors
Citations for ICI 199,441 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for ICI 199,441 hydrochloride. Do you know of a great paper that uses ICI 199,441 hydrochloride from Tocris? If so please let us know.