Antimalarials

Antimalarials are used to treat malaria, a disease caused by protozoan parasites of the Plasmodium genus, which are transmitted by female Anopheles mosquitoes. Most of these compounds target the erythrocytic stage of the infection. Quinoline derivatives such as a chloroquine and mefloquine act by accumulating in the parasite food vacuole and inhibiting the biocrystallization of hemozoin, a breakdown product of hemoglobin, resulting in accumulation of cytotoxic heme. The action of Artemisinin, a Chinese herb, and its derivatives appears to involve the heme-mediated cleavage of endoperoxide bridges to produce free radicals.

Products
Cat. No. Product Name / Activity
6818 Artemether
Antimalarial; also inhibits neuroinflammation
6827 Artesunate
Antimalarial; suppresses ROS-induced activation of the NLRP3 inflammasome
4109 Chloroquine diphosphate
Antimalarial; inhibits apoptosis and autophagy
3387 Gedunin
Antimalarial; Hsp90 inhibitor
5648 Hydroxychloroquine sulfate
Antimalarial; autophagy inhibitor; also TLR9 inhibitor
7492 Lomitapide mesylate
Inhibits hemozoin formation in P.falciparum and growth of PfNF54 and Pf K1 strains
6856 α-Mangostin
Xanthone derivative; antimalarial
6819 Mefloquine hydrochloride
Antimalarial; inhibits protein synthesis in P falciparum; also gap channel blocker
3213 Methylene Blue
Antimalarial
7629 Panobinostat
Antimalarial; pan-histone deacetylase inhibitor
4114 Quinine hydrochloride
Antimalarial
6566 STAD 2
Antimalarial; also AKAP disruptor; cell permeable