Antimalarials are used to treat malaria, a disease caused by protozoan parasites of the Plasmodium genus, which are transmitted by female Anopheles mosquitoes. Most of these compounds target the erythrocytic stage of the infection. Quinoline derivatives such as a chloroquine and mefloquine act by accumulating in the parasite food vacuole and inhibiting the biocrystallization of hemozoin, a breakdown product of hemoglobin, resulting in accumulation of cytotoxic heme. The action of Artemisinin, a Chinese herb, and its derivatives appears to involve the heme-mediated cleavage of endoperoxide bridges to produce free radicals.

Literature (1)
Cat. No. Product Name / Activity
6818 Artemether
Antimalarial; also inhibits neuroinflammation
2668 Artemisinin
Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
6827 Artesunate
Antimalarial; suppresses ROS-induced activation of the NLRP3 inflammasome
6358 Atovaquone
Inhibits complex III of mitochondrial electron transport chain in parasites
4109 Chloroquine diphosphate
Antimalarial; inhibits apoptosis and autophagy
3387 Gedunin
Antimalarial; Hsp90 inhibitor
5648 Hydroxychloroquine sulfate
Antimalarial; autophagy inhibitor; also TLR9 inhibitor
6856 α-Mangostin
Xanthone derivative; antimalarial
6819 Mefloquine hydrochloride
Antimalarial; inhibits protein synthesis in P falciparum; also gap channel blocker
4114 Quinine hydrochloride
6566 STAD 2
Antimalarial; also AKAP disruptor; cell permeable

Literature for Antimalarials

Tocris offers the following scientific literature for Antimalarials to showcase our products. We invite you to request* your copy today!

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New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
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  • Nuclear Receptors
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  • Chemogenetics
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