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Antimalarials are used to treat malaria, a disease caused by protozoan parasites of the Plasmodium genus, which are transmitted by female Anopheles mosquitoes. Most of these compounds target the erythrocytic stage of the infection. Quinoline derivatives such as a chloroquine and mefloquine act by accumulating in the parasite food vacuole and inhibiting the biocrystallization of hemozoin, a breakdown product of hemoglobin, resulting in accumulation of cytotoxic heme. The action of Artemisinin, a Chinese herb, and its derivatives appears to involve the heme-mediated cleavage of endoperoxide bridges to produce free radicals.
|Cat. No.||Product Name / Activity|
|Antimalarial; also inhibits neuroinflammation|
|Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum|
|Antimalarial; suppresses ROS-induced activation of the NLRP3 inflammasome|
|Inhibits complex III of mitochondrial electron transport chain in parasites|
|Antimalarial; inhibits apoptosis and autophagy|
|Antimalarial; Hsp90 inhibitor|
|Xanthone derivative; antimalarial|
|6819||Mefloquine hydrochloride New|
|Antimalarial; inhibits protein synthesis in P falciparum; also gap channel blocker|
|Antimalarial; also AKAP disruptor; cell permeable|
Tocris offers the following scientific literature for Antimalarials to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.