H-7 dihydrochloride

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Cat.No. 0542 - H-7 dihydrochloride | C14H17N3O2S.2HCl | CAS No. 108930-17-2
Description: Protein kinase inhibitor
Chemical Name: (±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively.

Technical Data

M. Wt 364.29
Formula C14H17N3O2S.2HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 108930-17-2
PubChem ID 73332
InChI Key OARGPFMFRLLKPF-UHFFFAOYSA-N
Smiles Cl.Cl.CC1CNCCN1S(=O)(=O)C1=CC=CC2=CN=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.29 20
water 36.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036 PMID: 6238627

Quick et al (1992) The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem.Biophys.Res.Commun. 187 657 PMID: 1530632

Ratz et al (1990) Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J.Pharmacol.Exp.Ther. 252 253 PMID: 2299593


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2 Citations for H-7 dihydrochloride

Citations are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:

Belmeguenai and Hansel (2005) A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. Mol Pharmacol 25 10768 PMID: 16291950

Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Front Mol Neurosci 84 834 PMID: 24056996


Do you know of a great paper that uses H-7 dihydrochloride from Tocris? If so please let us know.

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Literature in this Area

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Pathways for H-7 dihydrochloride

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