Protein kinase inhibitor. IC50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μM respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 364.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.73 mL||27.45 mL|
|5 mM||0.55 mL||2.75 mL||5.49 mL|
|10 mM||0.27 mL||1.37 mL||2.75 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the products' biological activity.
Hidaka et al (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23 5036 PMID: 6238627
Quick et al (1992) The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source. Biochem.Biophys.Res.Commun. 187 657 PMID: 1530632
Ratz et al (1990) Effect of the kinase inhibitor, H-7, on stress, crossbridge phosphorylation, muscle shortening and inositol phosphate production in rabbit arteries. J.Pharmacol.Exp.Ther. 252 253 PMID: 2299593
If you know of a relevant reference for H-7 dihydrochloride, please let us know.
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Keywords: H-7 dihydrochloride, supplier, Protein, kinase, Broad, Spectrum, inhibitors, inhibits, Broad, Spectrum, Protein, Kinase, Inhibitors, Broad, Spectrum, Protein, Kinase, Inhibitors, Tocris Bioscience
2 Citations for H-7 dihydrochloride
Citations are publications that use Tocris products. Selected citations for H-7 dihydrochloride include:
Belmeguenai and Hansel (2005) A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. Mol Pharmacol 25 10768 PMID: 16291950
Barcomb et al (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Front Mol Neurosci 84 834 PMID: 24056996
Do you know of a great paper that uses H-7 dihydrochloride from Tocris? If so please let us know.
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