You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Rac inhibitor (IC50 = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 430.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.65 mL||23.23 mL||46.45 mL|
|2.5 mM||0.93 mL||4.65 mL||9.29 mL|
|5 mM||0.46 mL||2.32 mL||4.65 mL|
|25 mM||0.09 mL||0.46 mL||0.93 mL|
References are publications that support the biological activity of the product.
Castillo-Pichardo et al (2014) The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model. Transl.Oncol. 7 546 PMID: 25389450
Montalvo-Ortiz et al (2012) Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J.Biol.Chem. 287 13228 PMID: 22383527
If you know of a relevant reference for EHop 016, please let us know.
View Related Products by Product Action
Keywords: EHop 016, EHop 016 supplier, EHop016, Rac, inhibitors, inhibits, Vav2, GEFs, guanine, nucleotide, exchange, factors, Rac1, Rac3, Rho, 6248, Tocris Bioscience
Citations for EHop 016
Citations are publications that use Tocris products.
Currently there are no citations for EHop 016. Do you know of a great paper that uses EHop 016 from Tocris? Please let us know.
Reviews for EHop 016
There are currently no reviews for this product. Be the first to review EHop 016 and earn rewards!
Have you used EHop 016?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Fall/Winter 2018/2019)New
Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells