EHop 016

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Cat.No. 6248 - EHop 016 | C25H30N6O | CAS No. 1380432-32-5
Description: Rac inhibitor
Chemical Name: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Rac inhibitor (IC50 = 1.1 μM). Exhibits some selectivity for Rac1 and Rac3 over Cdc42. Blocks the interaction of Rac with guanine nucleotide exchange factor Vav2 in breast cancer cell lines expressing high levels of Rac activity and inhibits activity of Rac downstream effector PAK1. Also inhibits mammary tumor growth and metastasis in mice.

Technical Data

M. Wt 430.55
Formula C25H30N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1380432-32-5
PubChem ID 51031035
InChI Key AFTZZRFCMOAFCR-UHFFFAOYSA-N
Smiles CCN1C2=CC=C(NC3=NC(NCCCN4CCOCC4)=NC=C3)C=C2C5=CC=CC=C51

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.53 50

Preparing Stock Solutions

The following data is based on the product molecular weight 430.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.61 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Castillo-Pichardo et al (2014) The Rac inhibitor EHop-016 inhibits mammary tumor growth and metastasis in a nude mouse model. Transl.Oncol. 7 546 PMID: 25389450

Montalvo-Ortiz et al (2012) Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J.Biol.Chem. 287 13228 PMID: 22383527


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Keywords: EHop 016, EHop 016 supplier, EHop016, Rac, inhibitors, inhibits, Vav2, GEFs, guanine, nucleotide, exchange, factors, Rac1, Rac3, G, Proteins, (Small), GTPase, 6248, Tocris Bioscience

Citations for EHop 016

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