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(±)-α-Lipoic acid

Cat. No. 7044 Submit a Review Datasheet / COA / SDS
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Description: Liquid-liquid phase separated condensate modifier; reduces stress granule formation
Chemical Name: 1,2-Dithiolane-3-pentanoic acid
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for (±)-α-Lipoic acid

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Technical Data for (±)-α-Lipoic acid

M. Wt 206.32
Formula C8H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1077-28-7
PubChem ID 864
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
Smiles OC(=O)CCCCC1CCSS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-α-Lipoic acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.63 100
ethanol 20.63 100

Preparing Stock Solutions for (±)-α-Lipoic acid

The following data is based on the product molecular weight 206.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.23 mL 48.47 mL
5 mM 0.97 mL 4.85 mL 9.69 mL
10 mM 0.48 mL 2.42 mL 4.85 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

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Product Datasheets for (±)-α-Lipoic acid

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for (±)-α-Lipoic acid

References are publications that support the biological activity of the product.

Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed

Dong et al (2020) Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 108 1711 PMID: 32640500

If you know of a relevant reference for (±)-α-Lipoic acid, please let us know.

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Citations for (±)-α-Lipoic acid

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