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(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 206.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.85 mL||24.23 mL||48.47 mL|
|5 mM||0.97 mL||4.85 mL||9.69 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
|50 mM||0.1 mL||0.48 mL||0.97 mL|
References are publications that support the biological activity of the product.
Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235
Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628
Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed
Dong et al (2020) Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 108 1711 PMID: 32640500
If you know of a relevant reference for (±)-α-Lipoic acid, please let us know.
Keywords: (±)-a-Lipoic acid, (±)-a-Lipoic acid supplier, Phase-separated, condensate, modifier, liquid-liquid, phase, separation, LLPS, liquid-like, solid-like, assemblies, probe, membrane-less, compartments, disrupts, dissolves, alpha, alfa, lipoic, acid, hematopoietic, haematopoietic, stem, cells, HSCs, antioxidant, ALA, Biochemicals, and, Molecular, Biology, Antioxidants, Stem, Cell, Proliferation, Hematopoietic, Cells, 7044, Tocris Bioscience
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