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Liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 206.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.85 mL||24.23 mL||48.47 mL|
|5 mM||0.97 mL||4.85 mL||9.69 mL|
|10 mM||0.48 mL||2.42 mL||4.85 mL|
|50 mM||0.1 mL||0.48 mL||0.97 mL|
References are publications that support the biological activity of the product.
Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235
Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628
Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease.
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Keywords: (±)-a-Lipoic acid, (±)-a-Lipoic acid supplier, Phase-separated, condensate, modifier, liquid-liquid, phase, separation, LLPS, liquid-like, solid-like, assemblies, probe, membrane-less, compartments, disrupts, dissolves, Biochemicals, and, Molecular, Biology, 7044, Tocris Bioscience
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Literature in this Area
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