(±)-α-Lipoic acid

Pricing Availability   Qty
Description: Liquid-liquid phase separated condensate modifier; reduces stress granule formation
Chemical Name: 1,2-Dithiolane-3-pentanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for (±)-α-Lipoic acid

(±)-α-Lipoic acid (ALA) is a liquid-liquid phase separated condensate modifier. Reduces stress granule formation in HeLa cells. Also stimulates mitochondrial biogenesis in 3T3-L1 adipocytes. Prevents dieback of FUS mutant motor neurons in culture and reverses motor defects in D. melanogaster expressing mutated human FUS. (±)-α-Lipoic acid is also an antixocidant. In hematopoietic stem cells (HSC) (±)-α-Lipoic acid reduces levels of reactive oxygen species (ROS) and inhibits apoptosis. It also promotes the generation of hematopoietic stem/progenitor cells from hPSCs in vitro and maintenance of functional cord blood HSCs ex vivo.

Technical Data for (±)-α-Lipoic acid

M. Wt 206.32
Formula C8H14O2S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1077-28-7
PubChem ID 864
InChI Key AGBQKNBQESQNJD-UHFFFAOYSA-N
Smiles OC(=O)CCCCC1CCSS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-α-Lipoic acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.63 100
ethanol 20.63 100

Preparing Stock Solutions for (±)-α-Lipoic acid

The following data is based on the product molecular weight 206.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.85 mL 24.23 mL 48.47 mL
5 mM 0.97 mL 4.85 mL 9.69 mL
10 mM 0.48 mL 2.42 mL 4.85 mL
50 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for (±)-α-Lipoic acid

References for (±)-α-Lipoic acid

References are publications that support the biological activity of the product.

Biewenga et al (1997) The pharmacology of the antioxidant lipoic acid. Gen.Pharmacol. 29 315 PMID: 9378235

Shen et al (2011) Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. Br.J.Pharmacol. 162 1213 PMID: 21108628

Wheeler et al (2019) Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease. BioRXiv - paper not yet peer reviewed

Dong et al (2020) Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J.Leukoc.Biol. 108 1711 PMID: 32640500


If you know of a relevant reference for (±)-α-Lipoic acid, please let us know.

Keywords: (±)-a-Lipoic acid, (±)-a-Lipoic acid supplier, Phase-separated, condensate, modifier, liquid-liquid, phase, separation, LLPS, liquid-like, solid-like, assemblies, probe, membrane-less, compartments, disrupts, dissolves, alpha, alfa, lipoic, acid, hematopoietic, haematopoietic, stem, cells, HSCs, antioxidant, ALA, Biochemicals, and, Molecular, Biology, Antioxidants, Stem, Cell, Proliferation, Hematopoietic, Cells, 7044, Tocris Bioscience

Citations for (±)-α-Lipoic acid

Citations are publications that use Tocris products.

Currently there are no citations for (±)-α-Lipoic acid. Do you know of a great paper that uses (±)-α-Lipoic acid from Tocris? Please let us know.

Reviews for (±)-α-Lipoic acid

There are currently no reviews for this product. Be the first to review (±)-α-Lipoic acid and earn rewards!

Have you used (±)-α-Lipoic acid?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review