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Description: Selective PSC eliminating agent
Biological Activity for D-3
Selective PSC eliminating agent. Induces toxicity in cultured iPSCs and ESCs after 1 h of incubation, via an alkaline phosphatase-dependent mechanism. Only eliminates iPSCs in co-cultures with iPSC-derived neurons, cardiomyocytes or hepatocytes. Treated iPSC-derived cardiomyocytes transplanted into mice exhibit no residual teratoma formation.
Technical Data for D-3
| M. Wt | 870.88 |
| Formula | C48H47N4O10P |
| Sequence |
FFFY (Modifications: Phe-1 = N-terminal 2-Naphthylacetyl, Phe-1 = D-Phe, Phe-2 = D-Phe, Phe-3 = D-Phe, Tyr-4 = D-Tyr(PO3H2) |
| Storage | Store at -20°C |
| CAS Number | 1967815-98-0 |
| InChI Key | VSVONENCEIBGNL-RXTANASVNA-N |
| Smiles | OC(=O)[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)CC1=CC2=CC=CC=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for D-3
References for D-3
References are publications that support the biological activity of the product.
Kuang et al (2017) Efficient, selective removal of human pluripotent stem cells via ecto-alkaline phosphatase-mediated aggregation of synthetic peptides. Cell Chem.Biol. 24 685 PMID: 28529132
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Citations for D-3
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Literature in this Area
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Stem Cell Research Product Guide
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.