Discontinued Product

D-3 (Cat. No. 6582) has been withdrawn from sale for commercial reasons.
Description: Selective PSC eliminating agent
Literature (4)

Biological Activity for D-3

Selective PSC eliminating agent. Induces toxicity in cultured iPSCs and ESCs after 1 h of incubation, via an alkaline phosphatase-dependent mechanism. Only eliminates iPSCs in co-cultures with iPSC-derived neurons, cardiomyocytes or hepatocytes. Treated iPSC-derived cardiomyocytes transplanted into mice exhibit no residual teratoma formation.

Technical Data for D-3

M. Wt 870.88
Formula C48H47N4O10P
Sequence FFFY

(Modifications: Phe-1 = N-terminal 2-Naphthylacetyl, Phe-1 = D-Phe, Phe-2 = D-Phe, Phe-3 = D-Phe, Tyr-4 = D-Tyr(PO3H2)

Storage Store at -20°C
CAS Number 1967815-98-0
Smiles OC(=O)[C@@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)CC1=CC2=CC=CC=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for D-3

References are publications that support the biological activity of the product.

Kuang et al (2017) Efficient, selective removal of human pluripotent stem cells via ecto-alkaline phosphatase-mediated aggregation of synthetic peptides. Cell Chem.Biol. 24 685 PMID: 28529132

Keywords: D-3, D-3 supplier, D3, pluripotent, stem, cell, eliminating, agents, iPSCs, Other, Differentiation, Products, ESCs, and, iPSC, 6582, Tocris Bioscience

Citations for D-3

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Currently there are no citations for D-3.

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Literature in this Area

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