DSPE-PEG 2000 Maleimide

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: PEGylated DSPE with a maleimide reactive group
Chemical Name: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol-2000)]
Purity: ≥90% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for DSPE-PEG 2000 Maleimide

DSPE-PEG (2000) maleimide is a functionalized phospholipid-polymer conjugate. It comprises a 1,2-distearoyl-sn-glycero-PE (DSPE) covalently coupled to a linear polyethylene glycol (Mr 2000) with a maleimide-terminated end. It is used to synthesize antibody-coupled PEG (2000)-DSPE micelles that can be transferred into liposomes to generate immunoliposomes. DSPE-PEG (2000) maleimide can also be incorporated into the outer membrane of lipid nanoparticles (LNPs) for further bioconjugation. It is used in antibody-targeted LNP-mRNA systems to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo.

Technical Data for DSPE-PEG 2000 Maleimide

Formula (C2H4O)nC51H91N3O13P.NH4 or Na
Storage Store at -20°C
Purity ≥90% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DSPE-PEG 2000 Maleimide

Solubility Soluble to 10 mg/ml in ethanol with gentle warming and to 10 mg/ml in chloroform

Product Datasheets for DSPE-PEG 2000 Maleimide

References for DSPE-PEG 2000 Maleimide

References are publications that support the biological activity of the product.

Ishida et al (1999) A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. FEBS Lett. 460 129 PMID: 10571074

Rurik et al (2022) CAR T cells produced in vivo to treat cardiac injury. Science 375 91 PMID: 34990237

Herrera-Barrera et al (2023) Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates. Sci.Adv. 9 eadd4623 PMID: 36630502


If you know of a relevant reference for DSPE-PEG 2000 Maleimide, please let us know.

Keywords: DSPE-PEG 2000 Maleimide, DSPE-PEG 2000 Maleimide supplier, 474922-22-0, immunoliposome, liposome, CAR-T, cells, lipid, nanoparticle, LNP, DSPE, Biochemicals, and, Molecular, Biology, Lipid, Nanoparticles, 7947, Tocris Bioscience

Citations for DSPE-PEG 2000 Maleimide

Citations are publications that use Tocris products.

Currently there are no citations for DSPE-PEG 2000 Maleimide. Do you know of a great paper that uses DSPE-PEG 2000 Maleimide from Tocris? Please let us know.

Reviews for DSPE-PEG 2000 Maleimide

There are currently no reviews for this product. Be the first to review DSPE-PEG 2000 Maleimide and earn rewards!

Have you used DSPE-PEG 2000 Maleimide?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review