Cyclosporin H

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Cat.No. 6982 - Cyclosporin H | C62H111N11O12 | CAS No. 83602-39-5
Description: Enhances lentiviral transduction
Chemical Name: 5-(N-Methyl-D-valine)cyclosporin A
Purity: ≥97% (HPLC)
Literature (1)

Biological Activity

Viral transduction enhancer. Increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Displays an additive effect when combined with rapamycin (Cat. No. 1292) or prostaglandin E2 (Cat. No. 2296). Lacks immunosuppressant activity of cyclosporin A (Cat. No. 1101).

Technical Data

M. Wt 1202.64
Formula C62H111N11O12
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 83602-39-5
PubChem ID 6476564
Smiles [H][C@]1(NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC(=O)[C@]([H])([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@]([H])(C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@]([H])(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C1=O)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 120.26 100
ethanol 60.13 50

Preparing Stock Solutions

The following data is based on the product molecular weight 1202.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

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References are publications that support the biological activity of the product.

Petrillo et al (2018) Cyclosporine H overcomes innate immune restrictions to improve lentiviral transduction and gene editing in human hematopoietic stem cells. Cell Stem Cell. 23 820 PMID: 30416070

If you know of a relevant reference for Cyclosporin H, please let us know.

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