Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 296.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.37 mL||16.87 mL||33.74 mL|
|5 mM||0.67 mL||3.37 mL||6.75 mL|
|10 mM||0.34 mL||1.69 mL||3.37 mL|
|50 mM||0.07 mL||0.34 mL||0.67 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Kim et al (2007) Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol.Pharmacol. 72 62 PMID: 17429005
Shin et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69 193 PMID: 19118003
Zhang et al (2009) Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci.Letts. 452 90 PMID:
If you know of a relevant reference for Cryptotanshinone, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Cryptotanshinone, supplier, acetylcholinesterases, inhibitors, inhibits, Abeta, amyloid-beta, beta-amyloid, b-amyloid, AMP-activated, protein, kinases, AMPK, STAT3, signal, transducers, activators, transcription, factors, β-amyloid, amyloidb, amyloidβ, STAT, Tocris Bioscience
Citations for Cryptotanshinone
Citations are publications that use Tocris products.
Currently there are no citations for Cryptotanshinone. Do you know of a great paper that uses Cryptotanshinone from Tocris? If so please let us know.