Cryptotanshinone

Pricing Availability Delivery Time Qty
Cat.No. 3713 - Cryptotanshinone | C19H20O3 | CAS No. 35825-57-1
Description: STAT3 inhibitor. Also displays multiple other activities
Chemical Name: 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.

Technical Data

M. Wt 296.36
Formula C19H20O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 35825-57-1
PubChem ID 160254
InChI Key GVKKJJOMQCNPGB-JTQLQIEISA-N
Smiles O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.96 10

Preparing Stock Solutions

The following data is based on the product molecular weight 296.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.74 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2007) Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Mol.Pharmacol. 72 62 PMID: 17429005

Shin et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. 69 193 PMID: 19118003

Zhang et al (2009) Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci.Letts. 452 90 PMID:

Wong et al (2009) Cryptotanshinone, an acetylcholinesterase inhibitor from Salivia miltiorrhiza, ameliorates scopolamine-induced amnesia in morris water maze task. Planta Med. 76 288 PMID:


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View Related Products by Product Action

View all STAT Inhibitors

Keywords: acetylcholinesterases inhibitors inhibits Abeta amyloid-beta beta-amyloid b-amyloid AMP-activated protein kinases AMPK STAT3 signal transducers activators transcription factors β-amyloid amyloidb amyloidβ STAT

Citations for Cryptotanshinone

Citations are publications that use Tocris products.

Currently there are no citations for Cryptotanshinone. Do you know of a great paper that uses Cryptotanshinone from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for Cryptotanshinone

JAK-STAT

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.

Protocols

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