Cholinesterases
Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.
Inhibitors |
|
|---|---|
| Cat No | Product Name / Activity |
| 3069 | Acephate |
| Anticholinesterase insecticide | |
| 0388 | Ambenonium dichloride |
| Cholinesterase inhibitor | |
| 3713 | Cryptotanshinone |
| Acetylcholinesterase inhibitor. Also displays multiple other activities | |
| 4385 | Donepezil hydrochloride |
| Potent AChE inhibitor | |
| 0686 | Galanthamine hydrobromide |
| Cholinesterase inhibitor | |
| 4086 | PE 154 |
| Fluorescent, potent AChE and BChE inhibitor | |
| 2967 | Phenserine |
| Cholinesterase inhibitor | |
| 0622 | Physostigmine hemisulfate |
| Cholinesterase inhibitor | |
| 4440 | Rivastigmine tartrate |
| Dual AChE and BChE inhibitor | |
| 0965 | Tacrine hydrochloride |
| Cholinesterase inhibitor | |
Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it effectively terminates signal transmission at cholinergic synpases.
AChE is the target of organophosphate nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate Alzheimer's disease.
Literature for Cholinesterases
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