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Cholinesterases

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.

Products
Background
Literature (1)
Gene Data

Cholinesterase Inhibitors
Cat. No. Product Name / Activity
0388 Ambenonium dichloride
Cholinesterase inhibitor
4385 Donepezil hydrochloride
Potent AChE inhibitor
0686 Galanthamine hydrobromide
Cholinesterase inhibitor
0622 Physostigmine hemisulfate
Cholinesterase inhibitor
4440 Rivastigmine tartrate
Dual AChE and BChE inhibitor

Related Targets

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it effectively terminates signal transmission at cholinergic synpases.

AChE is the target of organophosphate nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate Alzheimer's disease.

External sources of pharmacological information for Cholinesterases :

    Literature for Cholinesterases

    Tocris offers the following scientific literature for Cholinesterases to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    Alzheimer's Poster

    Alzheimer's Poster

    Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

    Cholinesterase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Acetylcholin-esterase Human ACHE NM_015831 P22303
    Mouse Ache NM_009599 P21836
    Rat Ache NM_172009 P37136
    Butyrylcholin-esterase Human BCHE NM_000055 P06276
    Mouse Bche NM_009738 Q03311
    Rat Bche NM_022942 Q9JKC1