Cholinesterases

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.

Products
Background
Literature
Gene Data

Inhibitors

Cat. No. Product Name / Activity
3069 Acephate
Anticholinesterase insecticide
0388 Ambenonium dichloride
Cholinesterase inhibitor
3713 Cryptotanshinone
Acetylcholinesterase inhibitor. Also displays multiple other activities
4385 Donepezil hydrochloride
Potent AChE inhibitor
0686 Galanthamine hydrobromide
Cholinesterase inhibitor
4086 PE 154
Fluorescent, potent AChE and BChE inhibitor
2967 Phenserine
Cholinesterase inhibitor
0622 Physostigmine hemisulfate
Cholinesterase inhibitor
4440 Rivastigmine tartrate
Dual AChE and BChE inhibitor
0965 Tacrine hydrochloride
Cholinesterase inhibitor

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it effectively terminates signal transmission at cholinergic synpases.

AChE is the target of organophosphate nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate Alzheimer's disease.

External sources of pharmacological information for Cholinesterases :

    Literature for Cholinesterases

    Tocris offers the following scientific literature for Cholinesterases to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Neurodegeneration

    Neurodegeneration Product Guide

    A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

    • Alzheimer's disease
    • Parkinson's disease
    • Huntington's disease
    Alzheimer's

    Alzheimer's Poster

    Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

    Cholinesterase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Acetylcholin-esterase Human ACHE NM_015831 P22303
    Mouse Ache NM_009599 P21836
    Rat Ache NM_172009 P37136
    Butyrylcholin-esterase Human BCHE NM_000055 P06276
    Mouse Bche NM_009738 Q03311
    Rat Bche NM_022942 Q9JKC1