Cholinesterases

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3069 Acephate
Anticholinesterase insecticide
0388 Ambenonium dichloride
Cholinesterase inhibitor
3713 Cryptotanshinone
Acetylcholinesterase inhibitor. Also displays multiple other activities
4385 Donepezil hydrochloride
Potent AChE inhibitor
0686 Galanthamine hydrobromide
Cholinesterase inhibitor
4086 PE 154
Fluorescent, potent AChE and BChE inhibitor
2967 Phenserine
Cholinesterase inhibitor
0622 Physostigmine hemisulfate
Cholinesterase inhibitor
4440 Rivastigmine tartrate
Dual AChE and BChE inhibitor
0965 Tacrine hydrochloride
Cholinesterase inhibitor

Cholinesterases inactivate the neurotransmitter acetylcholine by catalyzing its hydrolysis to choline and acetic acid. Acetylcholinesterase (AChE) is found in erythroid cells and at neuronal synapses, whilst butyrylcholinesterase is mostly expressed in the liver. The high enzymatic rate of AChE means that it effectively terminates signal transmission at cholinergic synpases.

AChE is the target of organophosphate nerve agents such as sarin and VX. Clinically, AChE inhibitors have found a number of uses, with physostigmine used to treat glaucoma. AChE inhibitors are also used in the management of mild to moderate Alzheimer's disease.

Literature for Cholinesterases

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Cholinesterase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Acetylcholin-esterase Human ACHE NM_015831 P22303
Mouse Ache NM_009599 P21836
Rat Ache NM_172009 P37136
Butyrylcholin-esterase Human BCHE NM_000055 P06276
Mouse Bche NM_009738 Q03311
Rat Bche NM_022942 Q9JKC1