CORM 2

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Cat.No. 6117 - CORM 2 | C6Cl4O6Ru2 | CAS No. 22594-69-0
Description: Carbon monoxide-releasing molecule
Chemical Name: Tricarbonyldichlororuthenium(II) dimer
Datasheet
Citations
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Literature

Biological Activity

Carbon monoxide-releasing molecule. Causes vasodilatation in isolated aortic rings in vitro. Cytotoxic to smooth muscle cells in vitro after prolonged (24h) exposure. Exhibits antihypertensive effects in vivo. Reduces tight-junction disruption in intestinal mucosa in a rat sepsis model.

Technical Data

M. Wt 512.01
Formula C6Cl4O6Ru2
Storage Store at RT
CAS Number 22594-69-0
PubChem ID 10951331
InChI Key JYHHJVKGDCZCCL-UHFFFAOYSA-J
Smiles [Cl-][Ru++]1([Cl-][Ru++]([Cl-])([Cl-]1)(C#[O])(C#[O])C#[O])(C#[O])(C#[O])C#[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.2 100

Preparing Stock Solutions

The following data is based on the product molecular weight 512.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References

References are publications that support the biological activity of the product.

Zhang et al (2015) Carbon monoxide-releasing molecule-2 reduces intestinal epithelial tight-junction damage and mortality in septic rats. PLoS One 10 e0145988 PMID: 26720630

Motterlini et al (2002) Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ.Res. 90 E17 PMID: 11834719


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Citations for CORM 2

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