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CORM 2

Cat. No. 6117 Submit a Review Datasheet / COA / SDS
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Cat.No. 6117 - CORM 2 | C6Cl4O6Ru2 | CAS No. 22594-69-0
Description: Carbon monoxide-releasing molecule
Chemical Name: Tricarbonyldichlororuthenium(II) dimer
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Biological Activity for CORM 2

CORM 2 is a carbon monoxide-releasing molecule. Causes vasodilatation in isolated aortic rings in vitro. Cytotoxic to smooth muscle cells in vitro after prolonged (24h) exposure. Exhibits antihypertensive effects in vivo. Reduces tight-junction disruption in intestinal mucosa in a rat sepsis model.

Technical Data for CORM 2

M. Wt 512.01
Formula C6Cl4O6Ru2
Storage Store at RT
CAS Number 22594-69-0
PubChem ID 10951331
InChI Key JYHHJVKGDCZCCL-UHFFFAOYSA-J
Smiles [Cl-][Ru++]1([Cl-][Ru++]([Cl-])([Cl-]1)(C#[O])(C#[O])C#[O])(C#[O])(C#[O])C#[O]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CORM 2

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.2 100

Preparing Stock Solutions for CORM 2

The following data is based on the product molecular weight 512.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.2 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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References for CORM 2

References are publications that support the biological activity of the product.

Zhang et al (2015) Carbon monoxide-releasing molecule-2 reduces intestinal epithelial tight-junction damage and mortality in septic rats. PLoS One 10 e0145988 PMID: 26720630

Motterlini et al (2002) Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ.Res. 90 E17 PMID: 11834719

If you know of a relevant reference for CORM 2, please let us know.

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Citations for CORM 2

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