Cilnidipine

Pricing Availability Delivery Time Qty
Cat.No. 2629 - Cilnidipine | C27H28N2O7 | CAS No. 132203-70-4
Description: Ca2+ channel blocker (dual L/N-type)
Alternative Names: FRC 8653
Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Compound Libraries

Cilnidipine is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 492.52
Formula C27H28N2O7
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 132203-70-4
PubChem ID 2752
InChI Key KJEBULYHNRNJTE-UHFFFAOYSA-N
Smiles COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.25 100
ethanol 4.92 10

Preparing Stock Solutions

The following data is based on the product molecular weight 492.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.3 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Murai et al (2000) Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine. Brain Res. 854 6 PMID: 10784100

Takahara et al (2004) Neuroprotective effects of a dual L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain ischemia model. Biol.Pharm.Bull. 27 1388 PMID: 15340224

Nap et al (2004) The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists. Fund.Clin.Pharmacol. 18 309 PMID:


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Citations for Cilnidipine

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Literature in this Area

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Pathways for Cilnidipine

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