Haloperidol hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 0931 - Haloperidol hydrochloride | C21H23ClFNO2.HCl | CAS No. 1511-16-6
Description: Antagonist, partly D2 selective
Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist.

Technical Data

M. Wt 412.33
Formula C21H23ClFNO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1511-16-6
PubChem ID 11495267
InChI Key JMRYYMBDXNZQMH-UHFFFAOYSA-N
Smiles Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.31 25mM with gentle warming
ethanol 4.12 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 412.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.13 mL 24.25 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Beresford and Ward (1987) Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 33 31 PMID: 3545764

IIyin et al (1996) Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Mol.Pharmacol. 50 1541 PMID: 8967976

Lynch and Gallagher (1996) Inhibition of N-methyl-D-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors. J.Pharmacol.Exp.Ther. 279 154 PMID: 8858988

Seeman and Van Tol (1994) Dopamine receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 4629 PMID:


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7 Citations for Haloperidol hydrochloride

Citations are publications that use Tocris products. Selected citations for Haloperidol hydrochloride include:

Kim et al (2012) Inhibition of tumor cell growth by Sigma1 ligand mediated translational repression. Biochem Biophys Res Commun 426 177 PMID: 22925888

Watson et al (2012) The transport of nifurtimox, an anti-trypanosomal drug, in an in vitro model of the human blood-brain barrier: evidence for involvement of breast cancer resistance protein. Neuropsychopharmacology 1436 111 PMID: 22200378

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Biochem J 10 e0141829 PMID: 26517556

Mishra et al (2015) Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands. Brain Res 466 263 PMID: 25510962

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. J Biomol Screen 40 766 PMID: 25249058

Oliver and Davies (2009) Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet 18 4576 PMID: 19729413

Balu et al (2008) Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments. Brain Res 1211 37 PMID: 18433734


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