Haloperidol hydrochloride

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Description: Dopamine antagonist; displays some D2 selectivity
Chemical Name: 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Purity: ≥98% (HPLC)
Citations (9)
Reviews (1)
Literature (2)

Biological Activity for Haloperidol hydrochloride

Haloperidol hydrochloride is a dopamine antagonist with selectivity for D2-like receptors (Ki values are 1.2, ~ 7, 2.3, ~ 80 and ~ 100 nM for D2, D3, D4, D1 and D5 receptors respectively). Subtype-selective NMDA antagonist. Identified as targeting human host proteins that interact with SARS-CoV-2.

Technical Data for Haloperidol hydrochloride

M. Wt 412.33
Formula C21H23ClFNO2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1511-16-6
PubChem ID 11495267
Smiles Cl.OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Haloperidol hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.31 25 with gentle warming

Preparing Stock Solutions for Haloperidol hydrochloride

The following data is based on the product molecular weight 412.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.7 mL 48.5 mL 97.01 mL
1.25 mM 1.94 mL 9.7 mL 19.4 mL
2.5 mM 0.97 mL 4.85 mL 9.7 mL
12.5 mM 0.19 mL 0.97 mL 1.94 mL

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Product Datasheets for Haloperidol hydrochloride

Certificate of Analysis / Product Datasheet
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References for Haloperidol hydrochloride

References are publications that support the biological activity of the product.

Beresford and Ward (1987) Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs 33 31 PMID: 3545764

IIyin et al (1996) Subtype-selective inhibition of N-MthD.-aspartate receptors by halope. Mol.Pharmacol. 50 1541 PMID: 8967976

Lynch and Gallagher (1996) Inhibition of N-MthD.-aspartate receptors by haloperidol: development and pharmacological characterization in native and recombinant receptors. J.Pharmacol.Exp.Ther. 279 154 PMID: 8858988

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 4629

Gordon et al (2020) A SARS-CoV-2 protein-protein interaction map reveals drug targets and drug repurposing. Nature 583 459 PMID: 32353859

If you know of a relevant reference for Haloperidol hydrochloride, please let us know.

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View all Non-selective Dopamine Antagonists

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⚠ WARNING: This product can expose you to chemicals including Haloperidol, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

9 Citations for Haloperidol hydrochloride

Citations are publications that use Tocris products. Selected citations for Haloperidol hydrochloride include:

Czysz et al (2015) Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains. J Biomol Screen 40 766 PMID: 25249058

Canfrán-Duque et al (2015) Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro. Biochem J 10 e0141829 PMID: 26517556

Mishra et al (2015) Theσ-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands. Brain Res 466 263 PMID: 25510962

Kurita et al (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci 15 1245 PMID: 22864611

Do you know of a great paper that uses Haloperidol hydrochloride from Tocris? Please let us know.

Reviews for Haloperidol hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Antagonist of D2R.
By Luiz Alexandre Magno on 10/26/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: PC12 cells

I used haloperidol hydrochloride to block D2 dopamine receptors, which increases phosphorylation of the Akt protein (see the western blot image).

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.