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Submit ReviewBI 605906
Description: Selective IKKβ inhibitor
Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for BI 605906
BI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).
External Portal Information for BI 605906
The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.
Compound Libraries for BI 605906
BI 605906 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for BI 605906
| M. Wt | 432.51 |
| Formula | C17H22F2N4O3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 960293-88-3 |
| PubChem ID | 23652660 |
| InChI Key | IYHHRZBKXXKDDY-UHFFFAOYSA-N |
| Smiles | CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BI 605906
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 |
Preparing Stock Solutions for BI 605906
The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for BI 605906
References for BI 605906
References are publications that support the biological activity of the product.
Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416
Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653
If you know of a relevant reference for BI 605906, please let us know.
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Keywords: BI 605906, BI 605906 supplier, BI605906, ikk-2, NF-kappaB, NF-kB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, ab, kinases, NF-κβ, IkB, Kinase, NF-kB/IkB, 5300, Tocris Bioscience
Citations for BI 605906
Citations are publications that use Tocris products.
Currently there are no citations for BI 605906. Do you know of a great paper that uses BI 605906 from Tocris? Please let us know.
Reviews for BI 605906
Average Rating: 5 (Based on 1 Review.)
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BI 605906 protects macrophages against LPS-induced inflammation.
By
Anonymous on 12/11/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages
RAW macrophages were incubated with 5 μM BI 605906 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with BI 605906.
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