BI 605906

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Cat.No. 5300 - BI 605906 | C17H22F2N4O3S2 | CAS No. 960293-88-3
Description: Selective IKKβ inhibitor
Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)

Biological Activity

Selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

Technical Data

M. Wt 432.51
Formula C17H22F2N4O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 960293-88-3
PubChem ID 23652660
Smiles CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 43.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416

Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653

If you know of a relevant reference for BI 605906, please let us know.

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View all IκB Kinase Inhibitors

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Citations for BI 605906

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