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Submit ReviewSelective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).
BI 605906 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
M. Wt | 432.51 |
Formula | C17H22F2N4O3S2 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 960293-88-3 |
PubChem ID | 23652660 |
InChI Key | IYHHRZBKXXKDDY-UHFFFAOYSA-N |
Smiles | CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.25 | 100 |
The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
References are publications that support the biological activity of the product.
Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416
Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653
If you know of a relevant reference for BI 605906, please let us know.
Keywords: BI 605906, BI 605906 supplier, BI605906, ikk-2, NF-kappaB, NF-kB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, ab, kinases, NF-κβ, IkB, Kinase, NF-kB/IkB, 5300, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for BI 605906. Do you know of a great paper that uses BI 605906 from Tocris? Please let us know.
Average Rating: 5 (Based on 1 Review.)
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RAW macrophages were incubated with 5 μM BI 605906 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with BI 605906.