Home / Pharmacology / Enzymes / Kinases / IκB Kinase / IκB Kinase Inhibitors / BI 605906

BI 605906

Cat. No. 5300 3 Citations 1 Review Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective IKKβ inhibitor
Chemical Name: 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BI 605906

BI 605906 is a selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).

External Portal Information for BI 605906

The Chemical Probes webpages of the Structural Genomics Consortium are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI 605906 is reviewed on the chemical probes website.

Compound Libraries for BI 605906

BI 605906 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BI 605906

M. Wt 432.51
Formula C17H22F2N4O3S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 960293-88-3
PubChem ID 23652660
InChI Key IYHHRZBKXXKDDY-UHFFFAOYSA-N
Smiles CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BI 605906

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.25 100

Preparing Stock Solutions for BI 605906

The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL
10 mM 0.23 mL 1.16 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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References for BI 605906

References are publications that support the biological activity of the product.

Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416

Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653

If you know of a relevant reference for BI 605906, please let us know.

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View all IκB Kinase Inhibitors

Keywords: BI 605906, BI 605906 supplier, BI605906, ikk-2, NF-kappaB, NF-kB, IkappaB, Kinases, Nuclear, Factor, Kappa, B, potent, selective, inhibitors, inhibits, inhibitory, factor-kappab, ab, kinases, NF-κβ, IkB, Kinase, NF-kB/IkB, 5300, Tocris Bioscience

3 Citations for BI 605906

Citations are publications that use Tocris products. Selected citations for BI 605906 include:

Mina J et al (2022) The PI3K/mTOR inhibitor Gedatolisib eliminates dormant breast cancer cells in organotypic culture, but fails to prevent metastasis in preclinical settings. Mol Oncol 16 130-147 PMID: 34058066

Derek A et al (2023) Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation. Br J Cancer 128 1236-1248 PMID: 36707636

Diti et al (2021) Syntaxin 4 Mediates NF-κB Signaling and Chemokine Ligand Expression via Specific Interaction With IκBβ. Diabetes 70 889-902 PMID: 33526588

Do you know of a great paper that uses BI 605906 from Tocris? Please let us know.

Reviews for BI 605906

Average Rating: 5 (Based on 1 Review.)

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BI 605906 protects macrophages against LPS-induced inflammation.
By Anonymous on 12/11/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Macrophages

RAW macrophages were incubated with 5 μM BI 605906 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with BI 605906.

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