Discontinued Product

Atovaquone (Cat. No. 6358) has been withdrawn from sale for commercial reasons.
Description: Inhibits complex III of mitochondrial electron transport chain in parasites
Chemical Name: 2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for Atovaquone

Broad spectrum antiparasitic and antipneumocystic compound. Inhibits bc1 complex (complex III) of mitochondrial electron transport chain (EC50 = 0.26 μM), causing cell death in Plasmodium yoelii infected erythrocytes. Also inhibits DHODH. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.72 μM).

Technical Data for Atovaquone

M. Wt 366.84
Formula C22H19ClO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 95233-18-4
PubChem ID 74989
Smiles O=C1C(O)=C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)C(C4=CC=CC=C41)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Atovaquone

References are publications that support the biological activity of the product.

Hughes et al (1990) Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis. Antimicrob.Agents Chemother. 34 225 PMID: 2327770

Srivastava et al (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J.Biol.Chem. 272 3961 PMID: 9020100

Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed

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Citations for Atovaquone

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Currently there are no citations for Atovaquone.

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