You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Broad spectrum antiparasitic and antipneumocystic compound. Inhibits bc1 complex (complex III) of mitochondrial electron transport chain (EC50 = 0.26 μM), causing cell death in Plasmodium yoelii infected erythrocytes. Also inhibits DHODH. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.72 μM).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 366.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.63 mL||68.15 mL||136.3 mL|
|1 mM||2.73 mL||13.63 mL||27.26 mL|
|2 mM||1.36 mL||6.81 mL||13.63 mL|
|10 mM||0.27 mL||1.36 mL||2.73 mL|
References are publications that support the biological activity of the product.
Hughes et al (1990) Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis. Antimicrob.Agents Chemother. 34 225 PMID: 2327770
Srivastava et al (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J.Biol.Chem. 272 3961 PMID: 9020100
Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed
If you know of a relevant reference for Atovaquone, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Atovaquone, Atovaquone supplier, atovaquone, antimalarial, antiparasitic, mitochondria, respiration, inhibitors, inhibits, DHODH, dihydroorotate, dehydrogenase, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, MERS, Oxidative, Phosphorylation, Dihyroorotate, Dehydrogenase, Antimalarials, 6358, Tocris Bioscience
Citations for Atovaquone
Citations are publications that use Tocris products.
Currently there are no citations for Atovaquone. Do you know of a great paper that uses Atovaquone from Tocris? Please let us know.
Reviews for Atovaquone
There are currently no reviews for this product. Be the first to review Atovaquone and earn rewards!
Have you used Atovaquone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells