You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Discontinued ProductAtovaquone (Cat. No. 6358) has been withdrawn from sale for commercial reasons.
Biological Activity for Atovaquone
Broad spectrum antiparasitic and antipneumocystic compound. Inhibits bc1 complex (complex III) of mitochondrial electron transport chain (EC50 = 0.26 μM), causing cell death in Plasmodium yoelii infected erythrocytes. Also inhibits DHODH. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.72 μM).
Technical Data for Atovaquone
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Atovaquone
References are publications that support the biological activity of the product.
Hughes et al (1990) Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis. Antimicrob.Agents Chemother. 34 225 PMID: 2327770
Srivastava et al (1997) Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J.Biol.Chem. 272 3961 PMID: 9020100
Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv - Paper not yet peer reviewed
View Related Products by Target
View Related Products by Product Action
Keywords: Atovaquone, Atovaquone supplier, atovaquone, antimalarial, antiparasitic, mitochondria, respiration, inhibitors, inhibits, DHODH, dihydroorotate, dehydrogenase, COVID-19, SARS-CoV-2, severe, acute, respiratory, syndrome, MERS, Oxidative, Phosphorylation, Dihyroorotate, Dehydrogenase, Antimalarials, Coronavirus, 6358, Tocris Bioscience
Citations for Atovaquone
Citations are publications that use Tocris products.
Currently there are no citations for Atovaquone.
Reviews for Atovaquone
There are currently no reviews for this product. Be the first to review Atovaquone and earn rewards!
Have you used Atovaquone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image