AS 8351

Pricing Availability Delivery Time Qty
Cat.No. 6044 - AS 8351 | C17H13N3O2 | CAS No. 796-42-9
Description: Induces reprogramming of fibroblasts into functional cardiomyocytes
Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR 99021, A83-01, BIX 01294, SC1, Y-27632, OAC2, SU 16f and JNJ 10198409. Iron chelator and putative inhibitor of KDM5B.

Technical Data

M. Wt 291.3
Formula C17H13N3O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 796-42-9
PubChem ID 5353827
InChI Key UBECDIQQXGETMR-PTNGSMBKSA-N
Smiles OC1=C(C2=CC=CC=C2C=C1)/C=N/NC(C3=CC=NC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.13 100
ethanol 1.46 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 291.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 6290 PMID: 7127239


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Keywords: AS 8351, supplier, AS8351, stem, cells, cardiac, cardiomyocytes, reprogramming, iron, chelators, reprogramming, differentiation, KDM, Reprogramming, Reprogramming, Tocris Bioscience

Citations for AS 8351

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Literature in this Area

Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for AS 8351

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