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Cytoprotectant against chemotherapy and radiotherapy. Reduces mitochondrial pyruvate use in hepatocytes but not hepatoma cells in vitro. Also inhibits angiogenesis.
Active metabolite is also available, WR 1065 (Cat. No. 3356)
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 214.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.67 mL||23.34 mL||46.68 mL|
|5 mM||0.93 mL||4.67 mL||9.34 mL|
|10 mM||0.47 mL||2.33 mL||4.67 mL|
|50 mM||0.09 mL||0.47 mL||0.93 mL|
References are publications that support the biological activity of the product.
Giannopoulou et al (2003) AmiF. inhibits angiogenesis in vivo. J.Pharmacol.Exp.Ther. 304 729 PMID: 12538828
Koukourakis et al (2016) Normal tissue radioprotection by AmiF. via Warburg-type effects. Sci.Rep. 6 PMID: 27507219
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Keywords: Amifostine, Amifostine supplier, amifostine, cytoprotectant, WR, 2721, protects, radiotherapy, chemotherapy, 112901-68-5, Biochemicals, and, Molecular, Biology, 6655, Tocris Bioscience
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