AKTide-2T

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Cat.No. 2422 - AKTide-2T | Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala | CAS No. 324029-01-8
Description: Akt/PKB substrate (synthetic)
Datasheet
Citations
Literature

Biological Activity

Peptide substrate for Akt/PKB. Acts as an inhibitor and mimics the optimal phosphorylation sequence of Akt.

Technical Data

M. Wt 1715.89
Formula C74H114N28O20
Sequence ARKRERTYSFGHHA
Storage Desiccate at -20°C
CAS Number 324029-01-8
PubChem ID 90488759
InChI Key HSEMWALZGKQWLK-SWWIKBNJSA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1715.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.91 mL 5.83 mL
5 mM 0.12 mL 0.58 mL 1.17 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Obata et al (2000) Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J.Biol.Chem. 275 36108 PMID: 10945990

Rane et al (2003) Heat shock protein 27 controls apoptosis by regulating Akt activation. J.Biol.Chem. 278 27828 PMID: 12740362


If you know of a relevant reference for AKTide-2T, please let us know.

Keywords: Akt PKB synthetic Protein Kinases B Enzyme Substrates activators Enzyme Substrates / Activators

Citations for AKTide-2T

Citations are publications that use Tocris products.

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for AKTide-2T

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