A 1070722

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Cat.No. 4431 - A 1070722 | C17H13F3N4O2 | CAS No. 1384424-80-9
Description: Highly potent, selective GSK-3 inhibitor
Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Compound Libraries

A 1070722 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.31
Formula C17H13F3N4O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1384424-80-9
PubChem ID 49830684
InChI Key VQPBIJGXSXEOCU-UHFFFAOYSA-N
Smiles O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 362.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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References

References are publications that support the biological activity of the product.

Bakker et al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568


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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: A 1070722, A 1070722 supplier, A1070722, glycogen, synthase, kinases, 3, inhibits, inhibitors, potent, selective, brain, penetrant, neuroprotective, tau, phosphorylation, beta, b, amyloid, Glycogen, Synthase, Kinase, 4431, Tocris Bioscience

Citations for A 1070722

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