A 1070722

Pricing Availability Delivery Time Qty
Cat.No. 4431 - A 1070722 | C17H13F3N4O2 | CAS No. 1384424-80-9
Description: Highly potent, selective GSK-3 inhibitor
Chemical Name: 1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Compound Libraries

A 1070722 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.31
Formula C17H13F3N4O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1384424-80-9
PubChem ID 49830684
InChI Key VQPBIJGXSXEOCU-UHFFFAOYSA-N
Smiles O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 362.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.8 mL 27.6 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bakker et al (2011) A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract) 568 PMID:


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View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: A1070722 glycogen synthase kinases 3 inhibits inhibitors potent selective brain penetrant neuroprotective tau phosphorylation beta b amyloid Glycogen Synthase Kinase 3

Citations for A 1070722

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Literature in this Area

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Pathways for A 1070722

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