6-Mercaptopurine

Pricing Availability Delivery Time Qty
Cat.No. 4103 - 6-Mercaptopurine | C5H4N4S | CAS No. 50-44-2
Description: Purine analog; inhibits DNA and RNA synthesis
Chemical Name: Purine-6(1H)-thione
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099).

Technical Data

M. Wt 152.18
Formula C5H4N4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-44-2
PubChem ID 3000241
InChI Key GLYGRBPLZURLDD-UHFFFAOYSA-N
Smiles S=C1C2C(N=CN2)N=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 15.22 100
DMSO 15.22 100
ethanol 1.52 10

Preparing Stock Solutions

The following data is based on the product molecular weight 152.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.57 mL 32.86 mL 65.71 mL
5 mM 1.31 mL 6.57 mL 13.14 mL
10 mM 0.66 mL 3.29 mL 6.57 mL
50 mM 0.13 mL 0.66 mL 1.31 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437


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Citations for 6-Mercaptopurine

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for 6-Mercaptopurine

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