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Submit Review6-Mercaptopurine
Description: Purine analog; inhibits DNA and RNA synthesis
Chemical Name: Purine-6(1H)-thione
Purity: ≥99% (HPLC)
Biological Activity
Inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099).
Technical Data
| M. Wt | 152.18 |
| Formula | C5H4N4S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 50-44-2 |
| PubChem ID | 3000241 |
| InChI Key | GLYGRBPLZURLDD-UHFFFAOYSA-N |
| Smiles | S=C1C2C(N=CN2)N=CN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.22 | 100 | |
| 1eq. NaOH | 15.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 152.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.57 mL | 32.86 mL | 65.71 mL |
| 5 mM | 1.31 mL | 6.57 mL | 13.14 mL |
| 10 mM | 0.66 mL | 3.29 mL | 6.57 mL |
| 50 mM | 0.13 mL | 0.66 mL | 1.31 mL |
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References
References are publications that support the biological activity of the product.
Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437
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Citations for 6-Mercaptopurine
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