Pricing Availability   Qty
Description: Purine analog; inhibits DNA and RNA synthesis
Chemical Name: Purine-6(1H)-thione
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity for 6-Mercaptopurine

6-Mercaptopurine is an inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 21.6 μM for PLpro deubiquitination activity).

Technical Data for 6-Mercaptopurine

M. Wt 152.18
Formula C5H4N4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 50-44-2
PubChem ID 3000241
Smiles S=C1C2C(N=CN2)N=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 6-Mercaptopurine

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 15.22 100
1eq. NaOH 15.22 100

Preparing Stock Solutions for 6-Mercaptopurine

The following data is based on the product molecular weight 152.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.57 mL 32.86 mL 65.71 mL
5 mM 1.31 mL 6.57 mL 13.14 mL
10 mM 0.66 mL 3.29 mL 6.57 mL
50 mM 0.13 mL 0.66 mL 1.31 mL

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Product Datasheets for 6-Mercaptopurine

References for 6-Mercaptopurine

References are publications that support the biological activity of the product.

Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437

If you know of a relevant reference for 6-Mercaptopurine, please let us know.

View Related Products by Product Action

View all DNA, RNA and Protein Synthesis Inhibitors

Keywords: 6-Mercaptopurine, 6-Mercaptopurine supplier, 6-Mercaptopurine, thiopurine, immunosuppressant, drug, 6-MP, purine, analog, chemotherapeutics, DNA,, RNA, and, Protein, Synthesis, Immunosuppressants, Papain-like, Proteases, 4103, Tocris Bioscience

Citations for 6-Mercaptopurine

Citations are publications that use Tocris products.

Currently there are no citations for 6-Mercaptopurine. Do you know of a great paper that uses 6-Mercaptopurine from Tocris? Please let us know.

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