6-Mercaptopurine
Biological Activity
Inhibitor of de novo purine synthesis through interference with DNA and RNA synthesis. Immunosuppressive and antileukemic drug; reduces the anticoagulation elicited by warfarin. Active metabolite of azathioprine (Cat. No. 4099).
Technical Data
| M. Wt | 152.18 |
| Formula | C5H4N4S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 50-44-2 |
| PubChem ID | 3000241 |
| InChI Key | GLYGRBPLZURLDD-UHFFFAOYSA-N |
| Smiles | S=C1C2C(N=CN2)N=CN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.22 | 100 | |
| 1eq. NaOH | 15.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 152.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.57 mL | 32.86 mL | 65.71 mL |
| 5 mM | 1.31 mL | 6.57 mL | 13.14 mL |
| 10 mM | 0.66 mL | 3.29 mL | 6.57 mL |
| 50 mM | 0.13 mL | 0.66 mL | 1.31 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Sahasranaman et al (2008) Clinical pharmacology and pharmacogenetics of thiopurines. Eur.J.Clin.Pharmacol. 64 753 PMID: 18506437
If you know of a relevant reference for 6-Mercaptopurine, please let us know.
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Citations for 6-Mercaptopurine
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
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