Azathioprine

Discontinued Product

Azathioprine (Cat. No. 4099) has been withdrawn from sale for commercial reasons.
Description: Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)
Chemical Name: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (2)

Biological Activity for Azathioprine

Azathioprine is a purine analog. Blocks DNA replication and the de novo pathway of purine synthesis. Immunosuppressive and anti-inflammatory drug; induces apoptosis in human T-lymphocytes. Prodrug of 6-mercaptopurine (Cat. No. 4103).

Compound Libraries for Azathioprine

Azathioprine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Azathioprine

M. Wt 277.26
Formula C9H7N7O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 446-86-6
PubChem ID 2265
InChI Key LMEKQMALGUDUQG-UHFFFAOYSA-N
Smiles CN1C=NC([N+]([O-])=O)=C1SC2=C3C(N=CN3)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Azathioprine

References are publications that support the biological activity of the product.

Maltzman and Koretzky (2003) Azathioprine: old drug, new actions. J.Clin.Invest. 111 1122 PMID: 12697731

Keywords: Azathioprine, Azathioprine supplier, Azathioprine, immunosuppressant, inhibits, DNA, synthesis, inhibitors, lymphocyte, purine, analog, DNA,, RNA, and, Protein, Synthesis, Immunosuppressants, 4099, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Azathioprine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Azathioprine

Citations are publications that use Tocris products.

Currently there are no citations for Azathioprine.

Reviews for Azathioprine

Average Rating: 5 (Based on 1 Review.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Azathioprine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Medium concentration of azathioprine slows growth but does not kill melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Azathioprine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells