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Cat.No. 4099 - Azathioprine | C9H7N7O2S | CAS No. 446-86-6
Description: Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)
Chemical Name: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
Purity: ≥99% (HPLC)

Biological Activity

Purine analog. Blocks DNA replication and the de novo pathway of purine synthesis. Immunosuppressive and anti-inflammatory drug; induces apoptosis in human T-lymphocytes. Prodrug of 6-mercaptopurine (Cat. No. 4103).

Compound Libraries

Azathioprine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 277.26
Formula C9H7N7O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 446-86-6
PubChem ID 2265
Smiles CN1C=NC([N+]([O-])=O)=C1SC2=C3C(N=CN3)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 277.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.61 mL 18.03 mL 36.07 mL
5 mM 0.72 mL 3.61 mL 7.21 mL
10 mM 0.36 mL 1.8 mL 3.61 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Maltzman and Koretzky (2003) Azathioprine: old drug, new actions. J.Clin.Invest. 111 1122 PMID: 12697731

If you know of a relevant reference for Azathioprine, please let us know.

Keywords: Azathioprine immunosuppressant inhibits DNA synthesis inhibitors lymphocyte purine analog DNA, RNA and Protein Synthesis

Citations for Azathioprine

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Currently there are no citations for Azathioprine. Do you know of a great paper that uses Azathioprine from Tocris? If so please let us know.

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Azathioprine


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