Discontinued Product

Azathioprine (Cat. No. 4099) has been withdrawn from sale for commercial reasons.
Description: Purine analog; prodrug of 6-mercaptopurine (Cat. No. 4103)
Chemical Name: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
Purity: ≥99% (HPLC)
Reviews (1)
Literature (2)

Biological Activity for Azathioprine

Azathioprine is a purine analog. Blocks DNA replication and the de novo pathway of purine synthesis. Immunosuppressive and anti-inflammatory drug; induces apoptosis in human T-lymphocytes. Prodrug of 6-mercaptopurine (Cat. No. 4103).

Compound Libraries for Azathioprine

Azathioprine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Azathioprine

M. Wt 277.26
Formula C9H7N7O2S
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 446-86-6
PubChem ID 2265
Smiles CN1C=NC([N+]([O-])=O)=C1SC2=C3C(N=CN3)=NC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Azathioprine

References are publications that support the biological activity of the product.

Maltzman and Koretzky (2003) Azathioprine: old drug, new actions. J.Clin.Invest. 111 1122 PMID: 12697731

Keywords: Azathioprine, Azathioprine supplier, Azathioprine, immunosuppressant, inhibits, DNA, synthesis, inhibitors, lymphocyte, purine, analog, DNA,, RNA, and, Protein, Synthesis, Immunosuppressants, 4099, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Azathioprine, which is known to the State of California to cause cancer. For more information, go to

Citations for Azathioprine

Citations are publications that use Tocris products.

Currently there are no citations for Azathioprine.

Reviews for Azathioprine

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Medium concentration of azathioprine slows growth but does not kill melanoma cells in vitro.
By Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human

Azathioprine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.

review image

Literature in this Area

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