8MDP

Pricing Availability Delivery Time Qty
Cat.No. 4588 - 8MDP | C28H48N8O4 | CAS No. 29491-75-6
Description: Potent equilibrative nucleoside transporter (ENT) inhibitor
Chemical Name: 2,2',2'',2'''-[[4,8-Bis(hexahydro-1(2H)-azocinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively.

Technical Data

M. Wt 560.73
Formula C28H48N8O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 29491-75-6
PubChem ID 16756415
InChI Key KXOCTHJHIGLQKJ-UHFFFAOYSA-N
Smiles OCCN(CCO)C2=NC1=C(N3CCCCCCC3)N=C(N(CCO)CCO)N=C1C(N4CCCCCCC4)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.21 20

Preparing Stock Solutions

The following data is based on the product molecular weight 560.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.83 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID: 21539390

Lin et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949


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Keywords: 8MDP, supplier, ENT1, inhibitors, inhibits, potent, equilibrative, nucleoside, transporters, 1, 2, ENT2, transports, Nucleoside, Transporters, Nucleoside, Transporters, Tocris Bioscience

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