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Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 560.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||8.92 mL||44.58 mL||89.17 mL|
|1 mM||1.78 mL||8.92 mL||17.83 mL|
|2 mM||0.89 mL||4.46 mL||8.92 mL|
|10 mM||0.18 mL||0.89 mL||1.78 mL|
References are publications that support the biological activity of the product.
Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID: 21539390
Lin et al (2007) Synthesis, flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949
If you know of a relevant reference for 8MDP, please let us know.
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Keywords: 8MDP, 8MDP supplier, ENT1, inhibitors, inhibits, potent, equilibrative, nucleoside, transporters, 1, 2, ENT2, transports, Nucleoside, Transporters, 4588, Tocris Bioscience
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