NBMPR

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Cat.No. 2924 - NBMPR | C17H17N5O6S | CAS No. 38048-32-7
Description: Equilibrative nucleoside transporter 1 (ENT1) inhibitor
Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (1)

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Compound Libraries

NBMPR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 419.41
Formula C17H17N5O6S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 38048-32-7
PubChem ID 65407
InChI Key DYCJFJRCWPVDHY-LSCFUAHRSA-N
Smiles OC[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3SCC4=CC=C([N+]([O-])=O)C=C4)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 419.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375 PMID: 10722669

Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241 PMID: 17695509

Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyrid. analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949


If you know of a relevant reference for NBMPR, please let us know.

View Related Products by Product Action

View all Nucleoside Transporter Inhibitors

Keywords: NBMPR, NBMPR supplier, Equilibrative, nucleoside, transporter, 1, ENT1, inhibitors, inhibits, adenosines, reuptake, Purine, Transporters, Pyrimidine, Nucleoside, Monoamine, Neurotransmitter, NBTI, 2924, Tocris Bioscience

4 Citations for NBMPR

Citations are publications that use Tocris products. Selected citations for NBMPR include:

Aungraheeta et al (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood 128 2717 PMID: 27694321

Xiao et al (2019) Physiology and effects of nucleosides in mice lacking all four adenosine receptors. PLoS Biol 17 e3000161 PMID: 30822301

Baron et al (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. J Exp Bot 6 e1629 PMID: 25654762

Clasadonte et al (2014) Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci 34 1879 PMID: 24478367


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Literature in this Area

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