Equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 419.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.38 mL||11.92 mL||23.84 mL|
|5 mM||0.48 mL||2.38 mL||4.77 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375 PMID: 10722669
Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241 PMID: 17695509
Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906 PMID: 17636949
If you know of a relevant reference for NBMPR, please let us know.
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2 Citations for NBMPR
Citations are publications that use Tocris products. Selected citations for NBMPR include:
Clasadonte et al (2014) Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci 34 1879 PMID: 24478367
Baron et al (2015) The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. J Exp Bot 6 e1629 PMID: 25654762
Do you know of a great paper that uses NBMPR from Tocris? If so please let us know.
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